摘要
目的 探讨非小细胞肺癌根治术后支气管残端复发放射治疗的疗效及毒性反应.方法 21例根治术后支气管残端复发的非小细胞肺癌患者行放射治疗,19例采用体外照射,剂量为44～68 Gy/22～34次/5～7周.2例行支气管腔内近距离放疗.结果 33.3%（7/21）的患者肿瘤完全缓解,42.9%（9/21）的患者肿瘤部分缓解,症状缓解率为81.0%（17/21）,中位生存期为22个月,1、3、5年生存率分别为66.7%、26.6%、14.2%,7例患者死于远处转移,10例患者死于局部进展.5例伴有纵隔淋巴结的残端复发癌患者均于治疗后6个月内死亡.结论 非小细胞肺癌根治术后支气管残端复发行放射治疗安全有效,毒副反应可以耐受.不伴纵隔淋巴结的患者治疗后有可能长期生存.
Objective To evaluate the effect and toxic reaction of radiation for bronchial stump recurrence of non-small-cell lung cancer after complete resection. Methods 21 NCLC patients with bronchial stump recurrence were treated with radiation therapy. 19 patients were treated with external radiotherapy and the prescribed dose was 44～68 Gy in 22～34 fractions 5～7 weeks. 2 patients were treated with endobronchial brachytherapy. Results Seven of 21 （33.3%） patients showed a complete response,and 9 of 21（42.9% ） patients showed a partial response. The symptoms response rate was 81.0 %. Median survival time for all 21 patients is 22 months,and overall 1-year,3-year,5-year survival rotes were 66.7% ,23.8% ,14.2% ,respectively. 7 patients died from distant metastasis and 10 patients died from locoregional relapse. 5 patients with mediastinal lymph nodes died within 6 months after treatment. Conclusion Raditherapy is an effective and safe tool in the treatment of bronchial stump recurrent NCLC after curative resection. The toxic reactions can standed. Long survival could be expected only if there were no metastases in the mediastinal lymph nodes.
出处
《实用癌症杂志》
2006年第2期192-194,共3页
The Practical Journal of Cancer
关键词
非小细胞肺癌
放射治疗
手术
复发
支气管残端
Non-small-cell lung cancer
Radiation therapy
Surgery
Recurrence
Bronchial stump
