摘要
目的研究血管内皮生长因子C(VEGFC)在晚期卵巢癌原发灶和转移灶中的表达并进行比较,探讨其与晚期卵巢癌发生、发展及预后的关系。方法应用SP免疫组织化学技术检测52例晚期卵巢癌原发灶以及相应的大网膜转移灶中VEGFC的表达。结果VEGFC在52例卵巢上皮癌中原发灶的高表达率为21%(1152),其中透明细胞癌与黏液性癌相比有显著性差异(χ2=6.97,P<0.01);在转移灶的高表达阳性率为35%(1852),各种组织学类型之间无显著性差异(P>0.01)。卵巢癌原发灶和转移灶之间VEGFC表达无明显差异(P>0.05)。结论VEGFC在晚期卵巢癌组织中表达增高,原发灶与转移灶之间无明显差异。
Objective To investigate the expressions of vascular endothelial growth factor C （VEGF-C） in primary and metastatic sites of patients with ovarian cancer. Methods Expressions of VEGF-C in 52 patients with ovarian cancer including primary and metastatic sites were determined by immunohistechemistry. Results The high expression of VEGF-C in primary sites was 21% （ 11 of 52）, among which significant difference of VEGF-C expression was found between mucinous cystadenoma and clear-cell carcinoma （X^2 = 6.97, P 〈 0.01 ）. The high expression of VEGF-C in metastatic sites was 35% （ 18 of 52）, among which no significant difference of VEGF-C expression was found between primary and metastatic sites in patients with ovarian cancer （ P 〉 0.05）. Condusion The VEGF-C expression in metastatic sites may not reflect an aggressive biologic behavior in ovarian cancer.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2006年第4期429-431,共3页
Immunological Journal
基金
河北省卫生厅科技攻关项目(98028)
关键词
卵巢癌
血管内皮生长因子C
原发灶
转移灶
预后
Ovarian cancer
Vascular endothelial growth factor C
Primary
Metastasis
Prognosis
