摘要
目的探讨用人工材料硅橡胶框架(SF)修复较大面积气管壁缺损的可能性。方法将20只健康成年犬(气管缺损2.5cm×6.0cm-3.0cm×6.0cm)随机分为两组,实验组10只犬,用SF及胸骨舌骨肌筋膜修复；对照组10只犬,用“T”形硅胶管及胸骨舌骨肌筋膜瓣等修复。分别在术后4,8,16,24,48周处死动物,气管镜观察缺损修复区的炎症反应；光镜观察缺损修复区管腔面上皮修复情况。结果实验组修复的管腔面光滑、无肉芽增生,术后第8周修复区管腔面已被上皮细胞覆盖,其呼吸、发声及吞咽功能恢复良好,对照组“T”形管前、后端附近的管腔面有明显肉芽组织增生,拔出“T”形管后,动物即窒息死亡。结论SF具有良好的支撑功能,用胸骨舌骨肌筋膜作衬里,以SF为支架修复较大面积气管壁缺损是简便、有效的手术方法。目的探讨用人工材料硅橡胶框架(SF)修复较大面积气管壁缺损的可能性。方法将20只健康成年犬(气管缺损2.5cm×6.0cm-3.0cm－×6.0cm)随机分为两组,实验组10只犬,用SF及胸骨舌骨肌筋膜修复；对照组10只犬,用“T”形硅胶管及胸骨舌骨肌筋膜瓣等修复。分别在术后4,8,16,24,48周处死动物,气管镜观察缺损修复区的炎症反应；光镜观察缺损修复区管腔面上皮修复情况。结果实验组修复的管腔面光滑、无肉芽增生,术后第8周修复区管腔面已被上皮细胞覆盖,其呼吸、发声及吞咽功能恢复良好,对照组“T”形管前、后端附近的管腔面有明显肉芽组织增生,拔出“T”形管后,动物即窒息死亡。结论SF具有良好的支撑功能,用胸骨舌骨肌筋膜作衬里,以SF为支架修复较大面积气管壁缺损是简便、有效的手术方法。
Objective To explore the feasibility of artificial silastic framework （SF） in repair of large area of tracheal wall defects. Methods Twenty healthy adult dogs with tracheal defects for 2.5 cm × 6.0 cm-3.0 cm× 6.0 cm were randomly and equally divided into experimental group （ repaired with SF combined with sternohyoid fasciae） and control group （repaired with T-silastie tubule combined with sternohyoid faseial flap）. After the operation, the animals were sacrificed at the 4th, 8th, 16th, 24th, and 48th weeks respectively for harvesting the tracheae that were used for traeheoseopieally observing inflammatory reaction of the repaired defect area and light microscopically observing epithelium healing on the repaired defect area. Results In the experiment group, the repaired trachea was smooth, without proliferation of granulation; and at the 8th week, the repaired defect area was covered with epithelial cells, with good functional recovery of respiration, phonation and deglutition. In the control group, there was obvious proliferation of granulation on the tracheal surface near anterior and posterior ends of T-silastie tubule. The animals were under asphyxia to die with extraction of T-silastie tubule. Conclusions SF has excellent tracheal skeletal function. In the meantime, SF combined with sternohyoid fasciae is a simple but efl＇eetive method for repair of large area of tracheal wall defects.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2006年第7期519-522,共4页
Chinese Journal of Trauma
关键词
硅橡胶框架
修复
较大面积气管壁缺损
实验
Wounds and injuries, trachea
Implants, experimental
Silastie framework
