摘要
目的:探讨瘦素、红细胞膜Ca2+-ATP酶活性在妊娠期高血压疾病发病中的意义及相互关系。方法:采用放射免疫法测定38例妊娠期高血压疾病患者,36例正常孕妇的血清瘦素。采用生化方法提取红细胞膜,测定红细胞膜Ca2+-ATP酶活性。结果:妊娠期高血压疾病患者血清瘦素水平明显高于对照组(15.95±5.10ng/m l vs 11.33±2.93ng/m l),红细胞膜Ca2+-ATP酶活性明显低于对照组[1.38±0.19μmol.pi/(mg.h)vs 1.83±0.38μmol.pi/(mg.h)](P<0.01)。妊娠期高血压疾病患者血清瘦素与红细胞膜Ca2+-ATP酶活性呈负相关(r=-0.63)。结论:血清瘦素水平与妊娠期高血压疾病的发生有关;妊娠期高血压疾病患者红细胞膜Ca2+-ATP酶活性降低引起细胞内游离Ca2+浓度升高,导致妊娠期高血压疾病发生;妊娠期高血压疾病患者血清瘦素水平与红细胞膜Ca2+-ATP酶活性呈负相关,两者共同参与妊娠期高血压疾病的发病。
Objective： To study the significance of leptin and the activity of erythrocyte membrane Ca^2＋ -ATPase （EMCA）in the development of hypertensive disorder complicating pregnancy. Method： Radioimmunoassay was used to test the level of serum leptin and the activity of EMCA was determined chemically in 38 patients with hypertensive disorder complicating pregnancy and 36 normal pregnant women. Results：The level of serum leptin in hypertensive disorder complicating pregnancy was significantly higher than that in normal pregnant women （15. 95 ± 5. 10ng/ml vs 11.33 ＋2. 93ng/ml）. The average EMCA activity of hypertensive disorder complicating pregnancy was lower than normal pregnancy significantly[ 1.38 ＋0. 19μmol·pi/（mg·h） vs 1.83 ＋ 0. 38μmol · pi/（mg · h）]. There was negative correlation between the level of serum leptin and the activity of EMCA in hypertensive disorder complicating pregnancy （ r = -0.63 ）. Conclusion：The increment of serum leptin level may play a role in the development of hypertensive disorder complicating pregnancy. Inhibition of EMCA activity of erythroeyte in hypertensive disorder complicating pregnancy may increase cytoplasmic free calcium and contribute to the development of hypertensive disorder complicating pregnancy ; there is negative correlation between the level of serum leptin and the activity of EMCA in hypertensive disorder complicating pregnancy. Serum leptin and the erythroeyte membrane Ca^2＋ -ATPase activity may play a role in the development of hypertensive disorder complicating pregnancy.
出处
《现代妇产科进展》
CSCD
北大核心
2006年第5期359-361,共3页
Progress in Obstetrics and Gynecology
