摘要
目的评价圣.约翰草提取物治疗抑郁症的临床疗效和安全性。方法78例抑郁症患者随机分为2组,分别给予圣.约翰草提取物(路优泰)和盐酸阿米替林治疗,疗程8周。采用汉密顿抑郁量表(HAMD),汉密顿焦虑量表(HAMA),临床总体评定量表(CGI)评定临床疗效,不良反应评价用副反应量表(TESS)、实验室检查及体检。结果经8周治疗,圣.约翰草提取物组有效率为85.37%,阿米替林组为89.19%,两组比较差异无统计学意义(P>0.05)。圣.约翰草提取物抗焦虑症状的疗效明显优于阿米替林(P<0.01),不良反应轻微。结论圣.约翰草提取物是一种安全、有效、具有较好抗焦虑作用的抗抑郁剂。
Objective To evaluate the efficacy and safety of st. Johnswort extract in the treatment of depression. Methods Seventyeight patients with depression were randomly divided into st. Johnswort extract group and amitriptyline group and treated with corresponding drags for 8 weeks. Hawihon rating scales for depression and anxiety, and clinical global impression scale were used to evaluate the efficacy. Safety was evaluated using TESS, laboratory test results and physical examination. Results After 8 weeks＇ treatment, the response rates in st. Johnswort extract group and amitriptyline group were 85.37% and 89.19%, respectively. There were no significant differences between the two groups （ P 〉 0.05）. On the other hand, st. Johnswort extract showed higher efficacy against anxiety symptoms than amitriptytine （ P 〈 0.01）. The adverse effects of st. Johnswort extract were mild. Conclusion st. Johnswort extract is an effective and safe antidepressant with satisfactory effect on anxiety, symptoms.
出处
《武警医学》
CAS
2006年第6期412-415,共4页
Medical Journal of the Chinese People's Armed Police Force
