摘要
目的:分析近年来深入研究的几种影响局部骨代谢的细胞生长调节因子,通过探讨各种功能性分子间的作用和联系,从功能的角度了解其决定因素和影响因素,试图勾勒出骨细胞生长、存活、发挥功能的局部体液化学微环境。资料来源:应用计算机检索Medline1980-01/2002-12相关骨代谢调节因子的文献,检索词“Bonemetabolism,adjustingfactors”,并限定文献语言种类为English。同时计算机检索CBM1980-01/2002-12相关骨代谢调节因子的文献,检索词为“骨代谢,调节因子”,并限定语言种类为中文。资料选择:对资料进行初审,选取骨代谢调节因子的文献,开始查找全文。纳入标准:①骨代谢。②调节因子。排除标准:综述文献、重复研究、Meta分析类文章。资料提炼:共收集到57篇关于骨代谢调节因子的文献,纳入22篇符合标准的文献。资料综合:众多的激素、因子共同调节成骨细胞和破骨细胞的代谢活动,它们之间有着协同、促进、抑制的复杂关系,并形成网络。骨组织合成多种生长因子,在骨质疏松发病机制中起着重要作用。成纤维细胞生长因子有利于骨质的生长。血小板衍生生长因子在骨折修复过程中起重要作用。骨是转化生长因子β最大的组织来源和储存库。骨形态发生蛋白在骨间质细胞向成骨细胞转化过程、成骨细胞分化过程以及骨发育和骨形成中起着不可替代的作用。白细胞介素主要由吞噬细胞合成,为多肽类物质。推测P物质在骨的纵向生长过程中可能起调控作用。各种骨代谢影响因子均存在于骨组织中,因而任何时候骨细胞的微环境中都不是只出现某一种因子,也即骨组织代谢是由多种因子同时参与调节。结论:针对影响骨代谢各种功能性分子间的复杂网络关系,在微观领域进行分子结构功能模式的数字化、信息化的研究是其可行的途径,也是极其必要的。
OBJECTIVE： To analyze the deeply researched several cell growth regulatory factors that affect topical bone metabolism and knows the decisive factors and influential factors through exploring the function and relationship of all kinds of functional molecules. Also the article tries to outline the topical humoral chemical micro-cireumstance in which the bone cells grow, survive and develop their functions. DATA SOURCES： The literatures of bone metabolism regulatory factors were collected from the Medline database from January 1980 to December 2002 by using the key words of ＂Bone metabolism and adjusting factors＂ in English. Moreover, the literatures of bone metabolism regulatory factors were collected from the CBM database between January 1980 and December 2002 by using the key words of ＂Bone metabolism and adjusting factors＂ in Chinese. STUDY SELECTION： The literatures were selected primarily, and then literatures of bone metabolism regulatory factors were collected, and found the full texts. The standard papers included （1）bone metabolism and （2） regulatory factors. The excluded ＂papers were review, repeated study and Meta analytical papers. DATA EXTRACTION： The literatures of bone cell metabolism regulatory factors were 57, and 22 papers were accorded with the standard. DATA SYNTHESIS： Many hormones and factors together regulated the metabolism activity of osteoblast and osteoclast. They had the complicated relation for being in conjunction, promote, restraining, and form a network. Bone tissue combined with multiple growth factors, and played an important role in the onset of osteoperosis. Fibrohlast growth factors were of benefit to the sclerotic growth. Platelet-derived growth factor played an important role in the repair of fracture. Bone was the biggest source and reservoir pool of transforming growth factor-β. Bone morphogenetic protein was necessary in bone mesenchymal cells transforming into osteoblast, differentiation of osteoblast, bone development and bone formation. Interleukin mainly was synthesized with phagocytic cells, polypeptide substance. It was suspected that P substance might play a regulatory effect in bone longitudinal growth. Various bone metabolism influencing factors were in bone tissues, so there was not only one factor in microenvironment of bone cells at any time, namely, the bone metabolism was regulated by multiple factors together. CONCLUSION： Aiming at the complicated network relation that influencing various functional factors of the bone metabolism, it is feasibility and necessary to carry on the digital and informational study of function mode of the molecule structure in the microcosmic field.
出处
《中国临床康复》
CSCD
北大核心
2006年第25期143-146,共4页
Chinese Journal of Clinical Rehabilitation
