摘要
目的:评价血清脂蛋白(a)[Lp(a)]在冠心病(CHD)诊疗中的地位和作用。方法:取250例患者血清进行测定Lp(a)和总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),其中正常组63例,冠心病组89例,高血压病组52例,其它类心脏病组46例。结果:①冠心病组血清Lp(a)较其他3组均显著升高(P<0.01),高血压组和其它类心脏病组与正常组Lp水平比较,无显著统计学差异(P>0.05);②冠心病单支病变组、2支病变组、2支以上病变组各组间血清Lp(a)水平比较差异均有统计学意义;③冠心病非急性心肌梗死患者与急性心肌梗死患者血清Lp(a)浓度无明显差异(P>0.05);④多因素逐步回归分析表明,Lp(a)与TG、TC、HDL-C之间无显著相关。结论:高Lp(a)水平是冠心病的独立危险因子,对于预测冠心病的发生有一定的价值,但对于预测冠心病急性心血管病事件的发生却未见明显的优势。
Objective： To explore the diagnostic value of lipoprotein（a）[Lp （a）] in coronary heart disease. Methods： Venous blood samples were collected from 250 persons for measuring serum levels of Lp（a）,total cholesterol（TC）,high-density lipoprotein cholesterol （HDL-C）,low-density lipoprotein cholesterol（LDL-C） and triglycerides （TG）. Among them there were 63 normal persons,89 patients with coronary heart disease 52 with hypertension and and 46 with others cardiovascular diseases. Results： （1） Compared with other three groups, Lp（a） levels were significantly higher in coronary artery disease group（P〈0.01）;（2）The levels of Lp（a） were higher with the extent of coronary stenosis;（3）Serum Lp（a） levles did not differ between acute myocardial infarction and stable coronary artery disease（P〉0. 05） ;（4）No correlations were be observed between Lp （a） level and serum levels of total cholesterol （TC）, high-density lipoprotein cholesterol（HDL-C） or triglycerides （TG）. Conclusion： High serum Lp（a）level is an independent risk factor for cardiovascular disease and can be used for predicting coronary artery disease, but it has no advantage in predicting future cardiovascular events.
出处
《实用临床医学（江西）》
CAS
2006年第6期29-31,共3页
Practical Clinical Medicine
关键词
最心病
脂蛋白(a)
危险因子
coronary heart disease
lipoprotein（a）
risk factor
