摘要
目的:研究灵芪蠲肝液对急性肝损伤的保护作用机制。方法:用硫代乙酰胺复制大鼠急性肝损伤模型,检测肝功能、一氧化氮(NO)含量以及肝组织匀浆中丙二醛(MDA)、超氧化物歧化酶(SOD)水平并取肝组织做病理检查。结果:硫代乙酰胺急性肝损伤时,灵芪蠲肝液能使血清ALT、AST活性、TB il、MDA、NO水平明显降低,升高SOD水平;病理检查发现其能减轻肝细胞变性、坏死,减少炎细胞浸润。结论:灵芪蠲肝液通过减少氧自由基的产生,减少NO的产生,从而保护肝细胞膜。
Objective： To observe the mechanism of Lingqijuangan Liquor（LQL） on acute hepatic injury. Methods： Acute hepatic injury was induced by thioacetamide. Then hepatic functions and the levels of serum nitric oxide （NO） and 10% liver homogenates＇ malonyldialdehyde （MDA） and superoxide dismutuse（SOD） were detected. Take liver tissue to do pathological examination. Results： Compaired with model group, blood serum ALT and AST activities, TBil and NO levels and MDA levels in homogenates were significantly decreased by LQL; and SOD levels were obviously increased by LQL when livers were acute injuried. Pathological examination found that LQL can lighten hepatic cell denaturalization and putrescence and reduce inflammation cell infiltration. Conclusion： LQL can lighten the thioacetamide induced acute liver injury by decreasing production of oxygen free radicals and reducing production of NO so as to protect liver cellular membrane.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2006年第3期153-154,共2页
Pharmacology and Clinics of Chinese Materia Medica
