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CD_4^+CD_(25)^+T细胞在控制移植物抗宿主病发生发展及治疗中的作用 被引量：1

CD_4^+CD_(25)^+T cells' role in generation,development holding graft versus host disease (GVHD) and therapy
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摘要 异基因干细胞移植是急、慢性白血病及其他恶性血液病重要治愈的途径,但急慢性移植物抗宿主病(GVHD)是异基因干细胞移植的主要并发症,故控制急慢性GVHD的方法是干细胞移植工作者研究的重要问题。目前自发现CD+4CD2+5T细胞以来,很多学者对此进行大量的研究,得出喜人的结论,它可以治疗自身免疫性疾病,艾滋病,尤其在控制急慢性GVHD,又不减轻移植物抗白血病效应,且不影响干细胞的植入方面的应用很有前景,在急慢性GVHD发生发展及治疗方面有重要的作用。 Allo-stem cell transplantation is an important way that can cure acute and chronic leukemia and other malignant hematonosis.But acute and chronic GVHD is Allo-stem cell transplantation＇ s complication,so the ways holding graft versus host disease are important issues cellular transplant workers study. Now since finding CD4^＋CD25^＋T cells ,in which many scholars are studying, they have been yielding delighted conculsion. CD4^＋CD25^＋T cells may treat autoimmunity, Acquired Immune Deficiency Syndrome（AIDS）, especially holiding acute and chronic GVHD, and neither lessen graft versus leukemia, nor affect stem cell graft. It plays an important role in acute and chronic GVHD＇ s generation, development and therapy.
作者 王志红 冯凯 陈虎
机构地区 军事医学科学院附属医院造血干细胞移植科
出处 《白血病．淋巴瘤》 CAS 2006年第3期235-236,共2页 Journal of Leukemia & Lymphoma
关键词 白血病 恶性血液病 移植物抗宿主病 异基因干细胞移植 CD4^+CD25^+T细胞 Leukemia Malignant hematonosis Allo-stem cell transplantation Graft versus host disease CD4^＋CD25^＋T cells
分类号 R392 [医药卫生—免疫学]
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参考文献12

  • 1Taylor P A,Lees C J,Blazar B R,et al.The infusion of ex vive activated and expanded CD4^+ CD25^+ immune regulatory cells inhibit graftverus-host disease lethality[J].Blood,2002,99(10):3493-3499.
  • 2Pontoux C,Banz A,Papiernik M.Natural CD4^+ CD25^+ regulatory T cells control the burst of superantigen-induced cytokine production:the role of IL-10[J].Int Immunol,2002,4(2):233-239.
  • 3Willems F,Marchant A,Delville J P,et al.Interleukia-10 inhibit B7and intercellular adhesion moleculel expression on human monocytes[J].Eur J Immunol,1994,24(4):1007-1009.
  • 4Takayana T,Nishioka Y,Lu L,et al.Retroviral delivery of viral interleukia-10 into myeloid dendritic cells markedly inhibit theirs allostimulatory activity and promotes the induction of T-cell hyporesponsiveness[J].Transplantation,1998,66(12):1567-1579.
  • 5In vitro-expanded human CD4^+ CD25^+ T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLRcultrure[J].Blood,2004,104(2):453-461.
  • 6Stanzani M,Sergio L R,Rima M,et al.CD25 expression on donor CD4^+ or CD8^+ T cells is associated with an increased risk for graft-verushost disease after HLA-identical stem cell transplantation in human[J].Blood,103(3):1141-1146.
  • 7Polanczyk M J,Carson B D,Subramanian S,et al.Cutting edge:estrogen drives expansion of the CD4^+ CD25^+ regulatory T cell compartment[J].J Immunol,2004,173(4):2227.
  • 8Ermann J,Szanya V,Ford G S,et al. CD4^+ CD25^+ T cells facilitate the induction of T cell anergy[J].J Immunol,2001,167(8):4271-4275.
  • 9Taylor P A,Noelle R J,Blazar B R. CD4^+ CD25^+ immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade[J].J Exp Med,2001,193(11):1311-1318.
  • 10Sarween N,Chodos A,Raykundalia C,et al. CD4^+ CD25^+ cells controlling a pathogenic CD4 response inhibit cytokine differientiation,CXCR-3 expression,and tissue invasion[J].J Immunol,2004,173(5):2942-2952.

同被引文献90

  • 1王志东,冯四洲,周世勇,王玫,周征,翟文静,韩明哲.急性GVHD发生与未发生者移植物FOXP3 mRNA表达的差异性研究[J].中国实验血液学杂志,2006,14(6):1215-1220. 被引量：5
  • 2Joffre O, Gorsse N, Romagnoli P, et al. Induction of antigenspecific tolerance to bone marrow allografts with CD4^+ CD25^+ T lymphocytes. Blood, 2004 ; 103 ( 11 ) :4216 - 4221.
  • 3Gould DS, Auchincloss Jr H. Direct and indirect recognition: the role of MHC antigens in graft rejection. Immunology Today, 1999;20(2) : 77 -82.
  • 4Bykovskaia SN, Shurin GV, Graner S, et al.Differentiation of immunostimulatory stem-cell- and monocyte-derived dendritic ceils involves maturation of intracellular compartments responsible for antigen presentation and secretion. Stem Cells, 2002 ;20 (5) :380 - 393.
  • 5Merlo A, Tagliabue E, Menard S, et al. Matured human monocyte-derived dendritic cells ( MoDCs ) induce expansion of CD4^+ CD25^+ FOXP3^+ T cells lacking regulatory properties. Immunol Lett, 2008; 117(1) : 106 -113.
  • 6Marguti I, Yamamoto GL, da Costa TB, et al. Expansion of CD4^+ CD25^+ Foxp3 T cells by bone marrow-derived dendritic cells. Immunology, 2009 ; 127 ( 1 ) :50 - 61.
  • 7Liu C, Wang Q, Liu F, et al, The allogeneic but not syngeneic dendritic cells effectively generated regulatory T cells from total CD4^+ population without exogenous cytokines. Scand J Immunol, 2010;71(1) :12 -19.
  • 8Masteller EL, Warner MR, Ferlin W, et al. Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes. J Immunol, 2003 ;171 (10) : 5587 -5595.
  • 9Mallet-Designe VI, Stratmann T, Homann D, et al. Detection of low-avidity CD4^+ T ceils using recombinantartifcial APC: following the antiovalbumin immune response. J Immunol, 2003; 170 ( 1 ) : 123 - 131.
  • 10Tarbell KV, Yamazaki S, Olson K, et aL CD25^+ CD4^+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med, 2004; 199(11): 1467 -1477.

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白血病．淋巴瘤
2006年 第3期

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