摘要
目的探讨胰腺癌患者血清血清免疫抑制酸性蛋白(immunosuppressive acidic protein,IAP)和外周血CD4+CD25+T细胞的相关性及临床意义。方法分别采用ELISA法和流式细胞技术检测55例胰腺癌患者血清IAP水平和外周血CD4+CD25+T细胞数量并进行相关性分析,同时与胰腺良性疾病组和健康对照组比较。结果胰腺癌患者外周血中CD4+CD25+T细胞和血清IAP的表达水平明显高于胰腺良性疾病组和对照组(P<0.05),且与肿块的大小、远处转移及临床分期显著相关性(P<0.05),胰腺癌患者外周血CD4+CD25+T细胞数量和血清IAP的表达成正相关。结论胰腺癌患者CD4+CD25+T细胞和血清IAP的水平与肿瘤的浸润转移和病程发展有关,胰腺癌患者外周血中CD4+CD25+T细胞数量的增多可能诱导IAP表达水平的增高。
Objective To discuss the relationship and clinical significance between the serum level of immunosuppressive acidic protein （IAP） and CD4^＋ CD25^＋ cells in peripheral blood in the patients with pancreatic cancer. Methods The contents of serum IAP and the population of CD4^＋ CD25^＋ cells in peripheral blood in 55 patients with pancreatic cancer were detected respectively by ELISA and flow cytometry, the results were compared with that of pancreatic benign diseases group and health controls. The correlation of serum level of IAP with CD4^＋ CD25^＋ cells in peripheral blood was studyed. Results The contents of serum IAP and the population of CD4^＋ CD25^＋ ceils in peripheral blood in the patients with pancreatic cancer were significantly higher than that of pancreatic benign diseases group and health control group （P〈0.05）.There was significant correlation between the contents of serum IAP and the population of CD4^＋ CD25^＋ cells with tumor size,distant metastasis and clinicopathological stage （P〈0.05）. The population of CD4^＋ CD25^＋ cells was positively correlated with IAP level in patients （P〈0.05）. Conclusion The contents of serum IAP and the population of CD4^＋ CD25^＋ cells in peripheral blood are closely related to tumor invasion,metastasis and chnical stage （TNM）. The increase of the population of CD4^＋ CD25^＋ cells in patients may induce the increase of serum level of IAP.
出处
《中国热带医学》
CAS
2009年第5期843-844,共2页
China Tropical Medicine
