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依马替尼对c-Kit^+急性髓细胞白血病骨髓细胞凋亡的作用 被引量：2

Expression of survivin and smac in patients with acute myelogenous leukemia and study about apoptosis of STI571 in vitro
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摘要 目的观察依马替尼(STI571)体外对干细胞受体阳性(c-Kit+)急性髓细胞白血病(AML)患者骨髓细胞凋亡的作用。方法用RT-PCR法检测c-Kit+AML细胞抑凋亡基因SurvivinmRNA和促凋亡基因SmacmRNA的表达水平。结果抑凋亡基因SurvivinmRNA的表达水平下降,促凋亡基因SmacmRNA的表达水平上升。结论STI571能诱导c-Kit+AML细胞促凋亡基因SmacmRNA上调,抑凋亡基因SurvivinmRNA的表达水平下降,发挥促凋亡作用。 Objective To investigate the influence about apoptosis of STI571 on expression of c-Kit in bone marrow cells from patients with acute myelogenous leukemia （AML）. Methods RT-PCR was used to analyze the expression of survivin and smac mRNA on bone marrow cells from patients with AML after treatment with STI571. Results Survivin inhibits cell, apoptosis and smac induces cell apoptosis the expression of survivin mRNA decrease and smac mRNA increase. Conclusions STI571 induce apoptosis expression of c- Kit in bone marrow cells from patients with AML in a dose-dependent manner as well as a time-dependent msnner.
作者 马梁明 孟丽华 周永安 朱镭 鹿育晋 王宏伟 崔月娥
机构地区 山西医科大学第二医院血液科
出处 《白血病．淋巴瘤》 CAS 2006年第3期190-192,195,共4页 Journal of Leukemia & Lymphoma
关键词 依马替尼 干细胞受体阳性(c—Kit^+) 急性髓细胞白血病 骨髓细胞凋亡 Apoptosis c-Kit Bone marrow cells Acute myelogenous leukemia
分类号 R733.71 [医药卫生—肿瘤]
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参考文献11

  • 1Broudy V C.Stem cell factor and hematopoiesis[J].Blood,1997,90(4):1345-1364.
  • 2Bene M C,Bernier M,Casasnovas R O,et al.The reliability and specificity of c-Kit for he diagosis of acute myeloid leukemisa and undifferentiated leukemias[J].Blood,1998,92 (2):596-599.
  • 3Schwartz S,Heinecke A,Zimmermann M,et al.Expression of the cKit receptor (CD117) is a feature of almost all subtypers of de novoacute myelobastic leukemia (AML),including cytogenetically good-risk AML,and lasks prognostic signficance[J].leuk Lymphoma,1999,34(1,2):85-94.
  • 4Heinrich M C,Griffth D J,Draker B J,et al.Inhibition of c-Kit receptor tyrosine kinase activity by STI571,a selective tyrosine kinase inhibitor[J].Blood,2000,96(3):925-932.
  • 5Scappini B,Onida F,Kantarjian M.Effects of signal transduction inhibitor 571 in acute myelogenous leukemia cells[J].Clinical Cancer Research,2001,7(12):3884-3893
  • 6Tamm I,Wang Y,Sausville E,et al.IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas(CD95),Bax,caspases,and anticancer drugs[J].Cancer Res,1998,589(23):5315-5320.
  • 7Cater B Z,Milella M,Altieri D C,et al.Cytokine-regulated expression of survivin in myeloid leukemia[J].Blood,2001,97(9):2784-2790.
  • 8Islam A,Ito C A.Control of apoptosis and mitotic spindle checkpoint by survivin[J].Cancer Res,2000,19(5):617-623.
  • 9Yoo N J,Kim H S,Kim S Y,et al.Immunohistochemical analysis of Smac/ DIABLO expresssion in human carcinomas and sarcomas[J].APMIS,2003,111(3):382-388.
  • 10Jia L,Patwaari Y,Kelsey S M,et al.Role of smac in human keakaemic cell apoptosis and proliferation[J].Oncogene,2003,22(11):1589-1599.

同被引文献8

  • 1王锦军,王琳.白血病化疗药物新进展[J].现代医药卫生,2007,23(4):528-529. 被引量：2
  • 2Lo CF, Zeiem A, Kinchi A, et al. Progress in differentiation induction as a treatment for acute promylocytic leukemia[J]. J Cancer Res, 2002, 62(19): 1591-1599.
  • 3Kantarjian HM. Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia[J]. J Blood, 2002, 100(95): 1590-1601.
  • 4Scappini B, Onida F, Kantarjian M. Effects of signal transduetion inhibitor Sti571 in acute myelogenous leukemia cells[J]. J Clin Cancer Res, 2001,7(12): 3884-3893.
  • 5ManrizioA, Cianni J, Vermin I, et al. Tyrosine kinaseinhibitor (Sti571) potentials the pharmacologic activity of retinoic: zceel in acute promylocytic leukemia cells: effects on the degradation of RAR α and PML-RAR α [J]. Blood, 2001,99(97): 3234-3241.
  • 6张艳,江倩,邱镜滢,陈珊珊,江滨,黄晓军.甲磺酸伊马替尼治疗慢性粒细胞白血病附加异常Ph阳性克隆的预后意义[J].中华内科杂志,2007,46(8):648-650. 被引量：4
  • 7Manrizio A,Cianni J,Vermin I. Tyrosine kinase inhibitor (Sti571)potentiales the pharmacologic activety of relinoic:zceel in acute promylocytic leukemia cells:effects on the degradation of RARa and PML-RARa[J].Blood,2001,(97):3234-3241.
  • 8Cater B,Milella M,AlLieri DC. Cytokine-regulated expression of survivin in myeloid leukemia[J].Blood,2001,(09):2784-2790.doi:10.1182/blood.V97.9.2784.

引证文献2

白血病．淋巴瘤
2006年 第3期

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