摘要
目的探讨咳宁方对实验性小鼠镇咳、祛痰的药理作用。方法以小鼠氨水引咳法与小鼠酚红祛痰法,观察咳宁方的镇咳、祛痰作用。结果咳宁方组与蛇胆川贝液组比较可显著减少氨水引发小鼠咳嗽反应的次数、延长咳嗽潜伏期(P<0.01),增加小鼠呼吸道内酚红的排出量(P<0.05,P<0.01)。结论咳宁方具有明显的镇咳、祛痰作用,其中咳宁Ⅱ方的镇咳、祛痰作用强于咳宁I方,为临床治疗岭南外感咳嗽提供了药理学依据。
Objective To investigate the pharmacological effects of relieving cough and expelling phlegm of Kening Formula on experiment mice. Method To observe the effects of relieving cough and expelling phlegm of Kening Formula through ammonia water inducing cough and phenol red apophlegmating in mice. Result The numbers of mouse cough reflex induced by ammonia water were decreased significantly and the cough latency phase was prolonged in Kening Formula group than that in Shedanchuanbei Oral Solution group （P 〈 0. 01 ）, and the discharge of phenol red from mouse respiratory tract was increased in Kening Formula group （P 〈 0. 05, P 〈 0. 01 ）. Conclusion Kening Formula has significant effects of relieving cough and expelling phlegm. The effects of Kening Formula Ⅱ are stronger than that of Kening Formula Ⅰ. The study provided a pharmacological basis for the treatment of cough induced by cold in Lingnan area of China.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2006年第5期321-323,共3页
Journal of Beijing University of Traditional Chinese Medicine
基金
广东省中医药管理局科研基金重点资助项目(No.97184)
关键词
咳宁方
镇咳
祛痰
小鼠
Kening Formula
relieving cough
expelling phlegm
mice
