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脑缺血及再灌注损伤保护性药物的研究进展 被引量:4

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摘要 缺血性脑卒中发病率、病死率和致残率高,可引起生活质量的严重下降,给社会及家庭带来了沉重的经济负担,而临床上应用有效的药物却少之又少,为此缺血性脑卒中的保护性药物成为研究热点。本文主要综述了近几年临床前应用脑缺血及再灌注损伤保护药物的实验室结果,以期对临床试验及药物的研发提供线索,从而有助于提高脑卒中病人的存活率及生活质量。
出处 《国外医学(药学分册)》 2006年第3期184-186,共3页 Foreign Medical Sciences(Section of Pharmarcy)
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  • 1Amemiya S,Kamiya T,Nito C,et al.Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats[J].Eur J Pharmacol,2005,516(2):125-130.
  • 2Lee EJ,Chen HY,Lee MY,et al.Cinnamophilin reduces oxidative damage and protects against transient focal cerebral ischemia in mice[J].Free Radic Biol Med,2005,39(4):495-510.
  • 3Andrabi SA,Spina MG,Lorenz P,et al.Oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia[J].Brain Res,2004,1017(1/2):98-107.
  • 4Luo Y,Qin Z,Hong Z,et al.Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia[J].Neurosci Lett,2004,363(3):218-223.
  • 5Choi YB,Kim YI,Lee KS,et al.Protective effect of epigallocatechin gallate on brain damage after transient middle cerebral artery occlusion in rats[J].Brain Res,2004,1019(1/2):47-54.
  • 6Thiyagarajan M,Sharma SS.Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats[J].Life Sci,2004,74(8):969-985.
  • 7Furuichi Y,Noto T,Li JY,et al.Multiple modes of action of tacrolimus (FK506) for neuroprotective action on ischemic damage after transient focal cerebral ischemia in rats[J].Brain Res,2004,1014(1/2):120-130.
  • 8Yulug B,Kilic U,Kilic E,et al.Rifampicin attenuates brain da-mage in focal ischemia[J].Brain Res,2004,996(1):76-80.
  • 9Hong KW,Kim KY,Lee JH,et al.Neuroprotective effect of(2S,3S,4R)-N″-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N′-benzylguanidine(KR-31378),a benzopyran analog,against focal ischemic brain damage in rats[J].J Pharmacol Exp Ther,2002,301(1):210-216.
  • 10Li DQ,Bao YM,Zhao JJ,et al.Neuroprotective properties of catalpol in transient global cerebral ischemia in gerbils:dose-response,therapeutic time-window and long-term efficacy[J].Brain Res,2004,1029(2):179-185.

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