摘要
目的：比较硝苯地平缓释片与普通片治疗原发性高血压的疗效。方法：用单盲、交叉对照法治疗４２例原发性高血压病人（男性２２例，女性２０例，年龄５４±ｓ７ａ）。甲组先用缓释片２０ｍｇ，ｐｏ，ｂｉｄ×１４ｄ，间隔１ｄ，改服普通片１０ｍｇ，ｐｏ，ｔｉｄ×１４ｄ，乙组服药先后次序与甲组相反，剂量相同，疗程均为２９ｄ。结果：缓释片与普通片的降压有效率分别为９８％及６４％，有明显差异（Ｐ＜０．０５），降压幅度缓释片也高于普通片（Ｐ＜０．０１），其影响病人心率加快反应显著小于普通片（Ｐ＜０．０１），其他不良反应的发生率较低，程度也较轻。结论：硝苯地平缓释片（２０ｍｇ，ｂｉｄ）较普通片（１０ｍｇ，ｔｉｄ）更高效而安全。
AIM: To compare the efficacies of slow release form of nifedipine tablet (SRN) and conventional nifedipine (CN) on essential hypertention. METHODS: Forty-two patients (M 22, F 20, age 54±s 7 a) were divided two groups, A and B, by single blind and crossover test. A group was received SRN 20 mg, po,bid×14 d at first, after a day's interval,given CN 10 mg, po, tid×14 d. On the contrary, B group was given CN 10 mg,po,tid×14 d at first. Following one day taking no any drug, then from the sixteenth day on, SRN 20 mg, po, bid×14 d. Both A and B course of treatment were 29 d. RESULTS: Hypertension was reduced effectively in 98% with SRN and 64% with CN (P<0.05). Hypotensive effect of the retard tablet tended to be larger than conventional nifedipine as well (P<0.01), but adverse reaction of palpitation with SRN was much milder than which CN (P<0.01), CONCLUSION: Slow Release form of nifedipine is a very valuable and safe antihypertensive agent in long-terms therapy.
出处
《新药与临床》
CSCD
北大核心
1996年第2期85-88,共4页
关键词
原发性
高血压
硝苯地平
缓释片
疗效
nifedipine
hypertension
delayed-action preparations
cross-over studies
