摘要
[目的]研究铅暴露对儿童体内骨钙素的影响,了解重庆市儿童铅污染的状况。[方法]选择重庆市工业区和非工业区的幼儿园,调查了2-7岁儿童804例体内铅暴露情况,并同时观察其体内钙及骨钙素水平。[结果]非工业区儿童体内血铅含量[(65．29±24．74)μg／L]明显低于工业区儿童[(75．29±34．61)μg／L],而血钙则与之相反分别为 (2．53±0．34)、(2．38±0．22)m mol／L。统计分析后认为,铅和钙之间不存在典型的直线相关,而折线(趋势)图显示,血铅和血钙之间呈负相关。非工业区儿童血液中骨钙素含量(11．22±6．01)μg／L远低于工业区儿童(21．20±22．70)μg／L,两者比较差异有非常显著性(P<0．01),且与年龄性别相关。多元回归分析血铅对于骨钙素有一定的影响。[结论]铅可能通过调控儿童体内骨钙素的产生,从而影响儿童体内钙的吸收利用。
[objective] To study the effect of lead on children＇s calcium and osteocalein. [Methods] The blood lead levels in 804 children aged 2-7 years old selected from 4 kindergartens（ half in industrial area and another in nonindustrial are a）were detected. At the same time, the blood calcium and osteocalcin of the ehidren were measured. [Results] The blood lead levels of the children in nonindustrial area were lower than those in industrial area, but the blood calcium content were reversed, and the blood lead and calcium were negative correlation. The content of osteocalcin in industrial area＇s children were more than those in nonindustrial area. [Conclusion] Lead exposure has an impact on the metabolism of calcium in children, and the mechanism maybe that lead modulated the production of osteocalcin.
出处
《中国儿童保健杂志》
CAS
2006年第3期236-238,共3页
Chinese Journal of Child Health Care
基金
中国营养学会达能营养基金(2004)
关键词
铅暴露
钙
骨钙素
lead exposure
calcium
osteocalcin
