摘要
目的探讨凋亡抑制因子L ivin在喉鳞癌中的表达及临床意义。方法采用逆转录聚合酶链反应(RT-PCR)法检测40例喉癌患者喉鳞癌组织及外周血细胞中L ivin的表达,并以声带息肉患者和正常人外周血作对照。结果在40例喉鳞癌标本中,L ivinα在26例(65%)癌组织中表达阳性,在17例(42.5%)外周血细胞中表达阳性;L ivinβ在喉癌组织及外周血细胞和声带患者中均不表达。L ivinα的阳性表达率与喉癌患者的年龄、性别、肿瘤部位、分化程度无相关性(P>0.05),与临床分期、淋巴结转移呈正相关(P<0.05)。结论凋亡抑制因子L ivinα在喉鳞癌组织和血液中高表达且与喉癌淋巴结转移、临床分期密切相关。
Objective To explore the expression of inhibitor-of-apoptosis Livin in laryngeal squamous carcinoma and its clinical significance. Methods Expression of Livin was detected in 40 laryngeal squamous carcinoma tissues which were confirmed by pathological examination and the corresponding peripheral blood cell as wells as 40 polyp of vocal cord and peripheral blood cells of normal people as control by RT-PCR. Results Livin 13 was not detected in tissues and peripheral blood cells of patients with laryngeal squamous carcinoma and polyp of vocal cord. Livin α was detected in 26 of 40 （65%） carcinoma tissues and 17 of 40 （42.5%） periph eral blood from the patients with laryngeal carcinoma. Livin ot expression had no relationship with age, sex, tumor size and histological grade （ P 〉 0. 05 ）, but had positive relationship with the clinical stages and lymphatic metastasis of the tumor. Conclusion Livin ot is highly expressed in the tissues and peripheral blood cell from the patients of laryngeal squamous carcinoma, which is closely related to the clinical stages and lymphatic metastasis of the tumor.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2006年第11期1226-1228,共3页
Journal of Third Military Medical University
基金
重庆市科委资助项目(2005)~~
关键词
凋亡抑制因子
LIVIN
喉鳞癌
逆转录聚合酶链反应
apoptosis inhibitor
Livin
laryngeal squamous carcinoma
reverse transcriptase polymerase chain reaction
