摘要
目的探讨利培酮联合小剂量万拉法新治疗精神分裂症阴性症状的临床疗效和安全性.方法将40例精神分裂症患者随机分为治疗组（利培酮＋文拉法辛）和对照组（利培酮）各20例,利培酮治疗剂量2～6mg·d^-1,万拉法新75～100mg·d^-1,疗程8w.治疗前后采用阴性症状量表和副反应量表评定临床疗效与不良反应.结果两组治疗后阴性症状量表总分和因子分均显著下降,差异有显著或极显著性（P＜0.05,0.01）;治疗组阴性症状量表总分、情感平淡、思维贫乏、意志缺乏、兴趣缺乏等因子分较对照组下降明显,差异有显著或极显著性（P＜0.05或0.01）.不良反应两组无显著性差异.结论利培酮联合小剂量万拉法新治疗精神分裂症阴性症状疗效优于单用利培酮治疗.
Objective To explore the efficacies and safety of combination of risperidone and small-dose venlafaxine in negative symptoms of schizophrenia. Methods 40 schizophrenics were randomly into treat- ment（n= 20, took risperidone combined with venlafaxine） and control group（n=20, did risperidone）, dosage of risperidone was 2-6mg/day and that of venlafaxine 75- 100mg/day for 8 weeks. Before and after treatment, efficacles and side effects were assessed using the Negative Syndrome Scale（NSS） and the Treatment Emergent Symptom Scale （TESS）. Results After treatment, total score and factors＇ scores of the NSS of both 2 groups obviously reduced, differences were significant and the most signiflcant（P〈0.05 or 0.01） ; compared with the control group, the total score of the NSS and factors＇ score of apathy, poverty of thought, abulia and interest blank obviously reduced in the treatment group, and differences were significant and the most significant（P〈0.05 or 0.01）. There was no difference in side effects between the 2 groups. Conclusion Combination of risperidone and small-dose venlafaxine is better than single risperidone in the treatment of negative symptoms of schizophrenia.
出处
《临床心身疾病杂志》
CAS
2006年第3期179-180,共2页
Journal of Clinical Psychosomatic Diseases
