摘要
目的:探讨利培酮对分裂症患者血清胆碱酯酶活力的影响及疗效。方法:采用自身对照的方法,分别于治疗前,治疗后1、2、3、4周测血清胆碱酯酶活力,并测BPRS和TESS。结果:治疗前与治疗后1、2、3、4周血清胆碱酯酶活力的比较差异无统计学意义(p>0.05)。治疗前与治疗后第2、4周BPRS比较差异均有显著性,t值分别为t=2.40,p<0.02;t=5.24,p<0.01。结论:利培酮对分裂症患者血清胆碱酯酶活力无明显影响,有显著疗效。
Objectives：To determine the influence of serum cholinesterase activity and clinical effect by risperidone in schizophrenic patients. Methods：Using control- self study to determine the serum cholinesterase activity before treatment and at 1,2,3,4 weeks after treatment. BPRS and TESS were used to measure clinical effects and side effects. Results： Serum cholinesterase activity had no significant difference between before treatment and at 1,2,3,4 weeks after treatment （P 〉 0.05 ）. BPRS demonstrated statistics significant difference between before treatment and at 2,4 week after treatment （ t = 2.40, P 〈 0.02 ; t = 5.24, P 〈 0.01 ）. Conclusions： Risperidone had no significant influence on serum cholinesterase activity and had good efficacy on schizophrenic patients.
出处
《中国民康医学》
2005年第9期489-490,共2页
Medical Journal of Chinese People’s Health
关键词
分裂症
利培酮
血清胆碱酯酶活力
schizophrenia
risperidone
serum cholinesterase activity
