摘要
自端粒酶发现至今的十几年中,人们对其结构和功能进行了系统的研究,发现端粒酶与肿瘤发生具有明显的关联。肿瘤细胞具有细胞周期失调的共同特点,而正常细胞脱氧核糖核酸在受到损伤后能够发生细胞周期阻滞以及时修复损伤,即通过细胞关卡调控,这是保持基因组稳定的关键事件。细胞周期关卡调节异常可导致遗传改变,并可能导致细胞的恶性转化。本文就端粒酶激活、细胞周期失调对肿瘤形成的影响以及两者之间关系的研究做一综述。
Since the original discovery of telomerase, a clear association with cancer has been demonstrated. Cell-cycle dysregulation is a hallmark of tumor cells. The ability of normal cells to undergo cell-cycle arrest after damage to DNA is crucial for the maintenance of genomic integrity. The biochemical pathways that stop the cell cycle in response to cellular stressors are called checkpoints. Defective checkpoint function results in genetic modifications that contribute to tumorigenesis. This review summarizes the current knowledge about the relation of telomerase activity, dysregulation of Cell- cycle and tumorigenesis.
出处
《卫生研究》
CAS
CSCD
北大核心
2006年第3期380-383,共4页
Journal of Hygiene Research
基金
科技部973项目(No.2002CB512900)
关键词
端粒酶
细胞周期
永生化
肿瘤发生
telomerase, cell cycle, immortalization, tumorigenesis
