摘要
目的探讨子宫内膜样腺癌及癌前病变组织中PTEN蛋白表达的相互关系及意义。方法采用免疫组化SP法检测正常子宫内膜、内膜增生、非典型性增生和子宫内膜样腺癌组织中PTEN蛋白的表达。结果非典型性增生和子宫内膜样腺癌组中PTEN蛋白阳性表达率分别为50·0%和45·5%,两组中PTEN阳性表达均显著低于正常子宫内膜和子宫内膜增生组(P<0·001)。癌组中PTEN阳性表达的缺失与组织学分级(P<0·002)、肌层浸润深度或伴有转移(P<0·03)及临床分期有关(P<0·002)。结论PTEN表达缺失涉及了子宫内膜样腺癌的发生、发展过程,PTEN蛋白的检测可作为子宫内膜样腺癌的早期诊断、判断肿瘤生物学行为的生物学指标。
Objective To investigate the relationship between PTEN protein expression and its clinical significance of endometrioid adenoearcinoma and precancerous conditions.Methods The expression of PTEN proteins was tested by S-P immunohistochemistry on normal endometrium（30 eases）, endometrial hyperplasia（30 eases）, atypical hyperplasia（20 cases） and endometrioid adenocarcinoma （55 cases）.Results The positive expression rate of PTEN proteins in atypical hyperplasis and endometrioid adenocarcinoma groups was 50.0 % and 45.5 %, respectively. The expression of PTEN positively in atypical hyperphsia and endometrioid adenocardnoma groups was significantly lower than these of normal endometrium and endometrial hyperplasia groups（P〈0.001）. In endometrioid adenocardnoma the expression loss of PTEN protein positively was significantly associated with histological grade（P 〈 0.002 ）, muscles invasion or lymph node metastasis（P〈 0.03） and dinical stage（P〈0.002） .Conclusion The results suggest that the loss expression of FTEN protein is closely related to the generation, development and recurrence of endometrioid adenocarcinoma. Detections of PTEN protein might be a useful biomarker in the early diagnosis in predicting the biological behavior and prognosis of endometrioid adenocarcinoma and in guiding dinical treatment.
出处
《广西医学》
CAS
2006年第4期499-501,共3页
Guangxi Medical Journal
