摘要
本试验用反相高效液相法测定芬苯哒唑长效控释丸在山羊体内的药物动力学。在血浆中测到芬苯哒唑代谢产物亚砜和砜，其平均浓度分别为７．１７±１．５４ｍｇ／ｍｌ和３．８６±１．０３ｎｇ／ｍｌ，但未测出原药浓度。在瘤胃液中测出的芬苯哒唑平均浓度为２１９．００±１３０．８３ｎｇ／ｍｌ。结果表明芬苯哒唑长效控释九可以在山羊体内恒定释放药物１１０天以上。
High-performance liquid chromatography method was used for determination of fenbendazole and its sulfoxide and sulfone metabolites in 5 goats. Mean plasma concentrations of sulfoxide and sulfone were 7. 17±1.54mg/ml. 3.86±1 .03ng/ml after administrating the fenbendazole controlled-release bolus, the mobile phase used was acetonitrile/methanol/ 0. 05 M (NH4)2CO3=23/17/65. Fenbendazole was not detectable in plasma samples. Mean ruminal fluid concentration of fenbendazole was 219.00±130.83ng/ml. It showed that the bolus delivered fenbendazole steadily in the rumen of goats for 110 days.
出处
《中国兽医寄生虫病》
CAS
1996年第3期5-9,共5页
Chinese Journal of Veterinary Parasitology
关键词
芬苯哒唑
长效控释丸
药物动力学
山羊
寄生蠕虫
Fenbendazole controlled-release bolus
Fenbendazole
Fenbendazole sulfoxide Fenbendazole sulfone
HPLC
Pharmacokinetics
