摘要
用反相高效液相色谱法测定埃维菌素长效控制释放丸在血浆和胃液中的药物动力学，所测成分为埃维菌素Ｂ１ａ。流动相为乙腈：甲醇：水＝７２：１８：１０，紫外检测波长为２４５ｕｍ，流速１ｍｌ／ｍｉｎ。结果表明埃维菌素长效控释丸在绵羊体内稳定释放，可持续１１０天以上，血浆和胃液中埃维菌素Ｂ１ａ的浓度分别为８．３７±１．９０ｎｇ／ｍｌ和４１．２４±２３．４１ｎｇ／ｍｌ。
High-performance liquid chromatography method was used to determine avermectin B1a. in plasma and rumen fluid of sheeps. Acetonitrile/methanol/ water (72/18/10)was selected as mobile phrase with flow rate of 1 ml/min, wavelength of 245 um was chosen for uv-detector. Avermectin controlled release bolus delivered avermectin B1a steadily in the rumen of sheeps for 110 days. The mean levels of avermectin B1a in the plasma and rumen fluid of five sheeps were 8.37±1.90ng/ml and 41 .24±23 .41 ng/ml after administrating the bolus.
出处
《中国兽医寄生虫病》
CAS
1996年第2期4-7,共4页
Chinese Journal of Veterinary Parasitology
关键词
羊病
埃维菌素
长效控释丸
药物动力学
寄生虫
Avermectin controlled release bolus Avermectin B1a high pressure liquid chromatography pharmacokinetics
