摘要
目的研究我国西北汉族人群基质金属蛋白酶(matrixmetalloproteinase1,MMP1)基因-1607(1G→2G)多态与肺癌发生风险的关系。方法应用聚合酶链反应限制性片段长度多态性分析的方法,检测了150例肺癌患者和200名正常对照者MMP11G→2G多态的基因型,比较不同基因型与肺癌发生风险的关系。结果肺癌组2G/2G基因型频率要高于对照组(χ2=5.896,P<0.05),2G/2G基因型者患肺癌的风险是1G/2G和1G/1G基因型的1.77倍(OR=1.77;95%CI:1.12～2.91)。吸烟者中2G/2G基因型发生肺癌的风险是1G/2G和1G/1G基因型的3.20倍(OR=3.20;95%CI:1.50～6.82)。结论我国西北汉族人群MMP1基因-1607(1G→2G)多态性与肺癌易感性有关,2G/2G基因型可以增加肺癌发生风险。
Objective Matrix metalloproteinase 1 （MMP1） plays an important role in the development of lung cancer. This study was to investigate the relation to associate the single nucleotide polymorphism （SNP） in MMP1 gene with the susceptibility to lung cancer in Northwestern Chinese population of Hart nationality. Methods By using the methods of polymerase chain reaction-restriction fragment length polymorphism analysis （PCR-RFLP）, MMP1 - 1607 （1G→2G） polymorphisms in 150 patients with lung cancer, and 200 healthy controls were detected to evaluate the relationship between different genotypes and susceptibility of lung cancer. Results Individuals with 2G/2G genotype had 1.77-fold risk suffering from lung cancer, when compared with ones with 1G/2G and 1G/1G genotypes. Smokers with 2G/2G genotype exhibited 3.20-fold elevated risk for lung cancer（OR= 3.20; 95% CI 1.50-6.82）. Concision The - 1607（1G→2G） in promoter region of MMP1 is associated with susceptibility to lung cancer in Northwestern Chinese population of Han nationality. The genotype 2G/2G enhances the susceptibihty to lung cancer.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2006年第3期313-315,共3页
Chinese Journal of Medical Genetics
