摘要
背景与目的肺癌是世界范围内最常见的一种癌症。基质金属蛋白酶家族(Matrix metalloproteases,MMPs)在癌细胞的转移和扩散中都起到重要作用。MMPs基因多态性与癌症易感性的关系一直是研究的热点,而它们与肺癌易感性是否相关尚存在争议。为了更好地探讨MMPs基因多态性与肺癌易感性之间的关系,我们收集、整理先前学者研究的数据,并进行Meta分析。方法使用PubMed和MEDLINE数据库检索2009年3月以前的相关文献,按照纳入标准,全面搜索含有研究MMP1-16071G/2G、MMP2-1306C/T、MMP2-735C/T、MMP9-1562C/T多态性与肺癌易感性相关的信息。由至少两位评价员做独立文献筛查和资料提取,并交叉审核。使用RevMan(version5.0)软件进行统计分析。结果根据我们的检索条件,8篇文章符合我们的纳入标准。共有4467例肺癌患者和4051名正常对照个体被纳入当前的Meta分析。分析结果表明:MMP2-735C/T多态性与肺癌易感性显著相关,与野生型等位基因-735C相比,突变型等位基因T显著降低了肺癌的易感性(OR=0.72,95%CI:0.61-0.85,P=0.0001);MMP1-16071G/2G、MMP2-1306C/T和MMP9-1562C/T多态性并没有明显影响肺癌的发生。结论当前研究结果表明MMP2基因启动子区-735C/T多态性与肺癌易感性明显相关,MMP9基因-1562C/T多态性与肺癌易感性的关系还需进一步的研究。
Background and objective Lung cancer is one of the most common cancers worldwide, especially in China. It has been proved that matrix metalloproteases （MMPs） play a key role in malignant cell metastasis. There have been a considerable number of studies investigating MMP polymorphisms in relation to various cancers. However, the associations of MMP polymorphisms with risk of lung cancer are lack of consistency. The aim of this study is to assess the association of MMP polymorphisms with risk of lung cancer by conducting a Meta-analysis from all eligible casecontrol studies published to date. Methods To identify all studies that examined the association of polymorphisms in the promoter of MMP1, MMP2 and MMP9 with lung cancer, we conducted a computerized literature search of PubMed and MEDLINE database （before March, 2009）. Two investigators independently extracted the data and reached a consensus on all items. Results Eight case-control studies, including 4 467 lung cancer cases and 4 051 controls, were selected for Meta-analysis to better assess the purported associations of common MMPs polymorphisms with risk of lung cancer. Our results suggest that MMP2-735C/T polymorphism is significantly modified risk of lung cancer. Comparing with the wild -735C allele, the variant T allele decreased risk of developing lung cancer （OR=0.72, 95%CI： 0.61-0.85, P=0.0001）. Other polymorphisms, including MMP1-1607 1G/2G, MMP2-1306C/T and MMP9-1562C/T, arc not assoeiated with risk of lung cancer. Conclusion The present study indicates that the MMP2-735C/T polymorphism is associated with the risk of lung cancer. Lager studies should be required to warrant the association of MMP9-1562C/T polymorphism with risk of lung cancer.
出处
《中国肺癌杂志》
CAS
2009年第5期381-386,共6页
Chinese Journal of Lung Cancer
基金
国家自然科学基金(No.30672400)
江苏省自然科学基金(No.BK2008162)
江苏省教育厅“青蓝工程”
国家“十一五”科技攻关项目(No.2006BAI02A01)资助~~
