摘要
对感染了继发性细粒棘球蚴的小鼠，于吡喹酮（Ｐｒａ）５００ｍｇ／ｋｇ／ｄ、甲苯达唑（Ｍｅｂ）２５ｍｇ／ｋｇ／ｄ或阿苯达唑（Ａｌｂ）３００ｍｙｋｇ／ｄ治疗１４天后，取包囊液测定了其中１８种游离氨基酸的含量，发现吡喹酮组小鼠囊液中有２种氨基酸的浓度高于对照组，有３种氨基酸的浓度低于对照组。而甲苯达唑组和阿苯达唑组囊液中的氨基酸浓度均低于对照组，其中各有１４种和１３种氨基酸含量明显低于对照组，表明甲苯达唑和阿苯达唑可干扰细粒棘球蚴囊的氨基酸代谢。
Mice infected with secondary cyst of Echinococcus granulosus for 10 months were treated intra-gastrically with mebendazole (Meb)25 mg/kg/dx14,albendazole(Alb)300mg/kg/d x 14 or praziquantel(Pra) 500 mg/kg/dx 14.At 24h after the last medication,the mice were killed by bloodletting for collectionof the cysts.he cyst fluid was obtained from each cyst by needle aspiration for measurement of free aminoacid (FAA)contents.In Pra group,the contents of Glu and Cys were higher,while His,Tyr and Try wereless than those of corresponding FAA(s)in the control group. In Meb and Alb groups,the contents of 14 and13 FAA (s)were significantly less than those of corresponding FAA(s)in the control group. The results in-dicate that the effective antihydatid drugs,Meb and Alb,exhibit effects on the amino acid metabolism,result- ing in decrease of contents of FAA(s)in the cyst fluid.
出处
《地方病通报》
1996年第2期15-18,共4页
Endemic Diseases Bulletin
关键词
棘球蚴囊
氨基酸
阿苯达唑
甲苯达唑
吡喹酮
Echinococcus granulesus
Cyst fluid
Experimental therapy
Mebendazole
Albendazole
Praziquantel
Amino acid
