摘要
目的研究艾滋病病毒HIV-1耐药毒株的出现情况及其影响因素,为艾滋病抗病毒药物的合理应用及减少耐药毒株的出现提供科学依据。方法采用横断面调查方法和基因型分析法对随州市接受艾滋病抗病毒治疗和未接受抗病毒治疗的HIV-1感染者进行耐药性检测。结果共调查193例HIV-1感染者(109例接受艾滋病抗病毒治疗,84名未接受治疗),其中病毒载量>1 000 copies/ml的95例PCR阳性者进行了耐药检测,未治疗、终止治疗和正在进行治疗的总耐药率分别为10.3%、25%和53.3%。结论基因突变是HIV耐药性产生的主要原因。接受和未接受抗病毒治疗的HIV-1感染者均存在不同程度的耐药,正在接受治疗的病例耐药突变率及总的耐药相关突变率均高于未治疗的病例及已经终止治疗的病例。
Objective To investigate the resistance rate and influencing factors of HIV- 1 infected people and provide scientific evidence for antiretroviral therapy and reduce the drug-resisted stains. Methods Gene analysis and cross section investigation were conducted among 193 HIV-1 infected patients for drug-resistance. Results Viral load PCR results of 95 patients were over 1 000 copies/ml. The drug-resistance ratio of three groups were 10.3%, 25% and 53.3% respectively. Conclusions The ratio of resistance and total resistance in people receiving antiretroviral therapy were significantly higher than people who didn＇ t receive therapy and stopped antiretroviral therapy. The gene mutation was a key factor of drug-resistance.
出处
《疾病控制杂志》
2006年第3期259-261,共3页
Chinese Journal of Disease Control and Prevention
基金
湖北省科技攻关项目(2005AA301C50)
