摘要
目的：评价舒芬太尼复合丙泊酚静脉麻醉在尤痛人流术中的疗效和安全性。方法：选择ASAⅠ～Ⅱ级妊娠1～2个月自愿施行人流术的孕妇60例，随机分为治疗组和对照组，每组30例，对照组为丙泊酚＋芬太尼，治疗组为丙泊酚＋舒芬太尼，两组阿泊酚均采用2次推注法，首次给药至深镇静（45～60s内注完），2～3min后扩宫口时再追加50％诱导量，观察诱导过程及术中血压、心率、脉搏氧饱和度、呼吸频率、苏醒时间、丙泊酚用量、术后恶心呕吐、头晕、术后宫缩痛（采用VAS评分）。结果：丙泊酚用屠治疗组少于对照组（P〈0．05），呼吸抑制发生率对照组80％，治疗组50％，术后宫缩痛治疗组明显少于对照组，两组术中血压、心率、脉搏氧饱和度比较差异无显著性。结论：舒芬太尼合用丙泊酚静脉麻醉行无痛人工流产术可以减少丙泊酚用量和呼吸抑制的发生，镇痛效果显著，而不良反应未见增加。
Objective：To evaluate efficacy and safety of sufentanil as supplement to propofol anaesthesia in painless abortion. Methods ： 60 ASA Ⅰ -Ⅱ pregnant women undergoing painless abortion were and randomly divided into treatment group （n=30） and control group （n= 30）. Pregnant stage was in the first or second months. In the control group ,patients were administrated intravenously propofol and fentanyl. In the treatment group ,sufentanil was used in combination with propofol. Both groups were infused intravenously by two phases ,in first phases drug was used until patients were deeply sedated,in second phase （when uterocervical dilation）50% initial dose was boosted. Blood pressure ,heart rate ,SpO2 ,Breath frequency ,revival time ,propofol dosage ,post-operative nausea and vomiting ,vertigo and postoperative uterotonic pain（adopt VAS grade）in two groups were compared in inducing and maintaining phases. Results ;Propofol dosage ,postoperative uterotonic pain and rate of breath inhibition in treated group were less than those in control group（P〈0. 05）. However,it was of no statistical signifieanees in two groups for data of blood pressure, heart rate and SpOt. Conelusions：Sufentanil can reduce propofol dosage and respiratory inhibition rate,strengthen analgesia effect of propofol without more side effects when used as supplement to propofol anesthesia in painless induced abortion.
出处
《临床医药实践》
2006年第6期425-426,共2页
Proceeding of Clinical Medicine
