摘要
目的评价重组人干扰素α-2a凝胶(抗尖锐湿疣凝胶)预防尖锐湿疣复发的有效性和安全性。方法与安慰剂对照,尖锐湿疣患者经激光、冷冻或电灼清除疣体后,每日外用药物4次,疗程8周,再随访至第20周。共入选尖锐湿疣患者154例。结果在用药第2,4,8,12,16,20周,试验组复发率明显低于安慰剂组,统计学上有显著性差异。结论重组人干扰素α-2a凝胶对尖锐湿疣治愈后、预防复发的疗效肯定,耐受性好。
Objective To study the efficacy and safety of recombinant interferon α -2a gel in prevention of condyloma acuminata relapse. Methods Recombinant interferon α -2a gel or placebo was applied 4 times daily for 8 weeks after condyloma acuminata was clinically cleared by laser, cryotheropy or electrodesiccation, both treatment groups were followed up for 12 weeks. Results One hundred and fifty four cases were involved. The results showed that relapse rates of recombinant interferon α-2a gel were lower than that of placebo at week 2,4,8,12,16,20. The relapse rates between two groups had significant statistic differences. Conclusion Recombinant interferon α -2a gel is a topical drug with good efficacy, safety and tolerability in prevention of condyloma acuminata relapse.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2006年第2期109-111,共3页
The Chinese Journal of Clinical Pharmacology
关键词
重组人干扰素Α-2A
尖锐湿疣
复发
recombinant interferon α - 2a
condyloma acuminata
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