摘要
目的评价5%咪喹莫特乳膏治疗尖锐湿疣的疗效和安全性,并与2.5%5-氟脲嘧啶乳膏进行对照。方法对尖锐湿疣患者进行多中心、随机双盲、平行对照的临床试验研究。5%咪喹莫特乳膏试验组和2.5%5-氟脲嘧啶乳膏对照组均每周外用药物3次,共治疗8周。结果本研究共244例患者完成全部观察,其中,咪喹莫特组125例,5-氟脲嘧啶组119例。咪喹莫特组治疗后2、4、6、8周的痊愈率分别为52.00%、74.40%、81.60%、92.80%、有效率分别为79.20%、93.60%、97.60%、97.60%.5-氟脲嘧啶组治疗后2、4、6、8周的痊愈率分别为52.10%、70.59%,78.15%、89.92%、有效率分别为84.03%、94.12%、94.96%、97.48%。两组差异均无统计学意义(P>0.05)。不良事件主要为局部不良反应,如局部红斑、疼痛、糜烂,瘙痒等,未见系统性不良反应。结论5%咪喹莫特乳膏治疗尖锐湿疣疗效确切,使用方法简便,耐受性较好。
Objective To observe the clinical efficaey and safely of 5% imiquimod cream in topical treatment of condyloma acuminatum arid to compare it with 2.5% fluorouracil（5 FU） cream, Methods A randomized, double-blind, parallel group, muhi-eenter clinical study was conducted. The patients in the study and control groups topically vsed 5% imiquimod cream and 2.5% 5-FU cream, respectively, 3 times per week for 8 weeks, Two-hundred and forty-four patients with etmttyloma aeuminatum were enrolled into this trial. Of them. 125 received 5% imiquimod cream treatment and 119 used 2.5% 5-FU cream. Results The results showed that in the study group, the cure rates were 52.00%, 74,40%, 81.60% and 92.80% and the response rates were 79.20%, 93.60%, 97.60% and 97.60% for the 2-, 4-, 6- and 8-week treatment, respectively. In the 5-FU group, the cure rates were 52.10%, 70.59%, 78.15% and 89.92%, and the response rates were 84.03%, 94.12%, 94.96% and 97.48% for the 2-, 4-, 6- and 8 week treatment, respectively. There was no statistical differenee between the two groups （P〉0.05）. The side efteets were mainly local reactions, including erythema, pain, erosion, itching, etc, No systemic side effect was found. Conclusion 5% imiquimod cream is efleetive, convenient and safe in the treatment of condyloma aeuminatum.
出处
《国际皮肤性病学杂志》
2006年第1期3-5,共3页
International Journal of Dermatology and Venereology
关键词
尖锐湿疣
咪喹莫特
Condyloma acuminatumc
hniquimod
