1IKENOUE T,HIKIBA Y,KANAI F,et al.Functional analysis of mutations within the kinase activation segment of B-raf in human colorectal tumors[J].Cancer Res,2003,63 (23):8132-8137.
2IKAWA S,FUKUI M,UEYAMA Y,et al.B-raf,a new member of the raf family,is activated by DNA rearrangement[J].Mol Cell Biol,1988,8(6):2651-2654.
3DAVIES H,BIGNELL G R,COX C,et al.Mutations of the BRAF gene in human cancer[J].Nature,2002,417(6892):949-954.
4MERCER K E,PRITCHARD C A.Raf proteins and cancer:Braf is identified as a mutational target[J].Biochim Biophys Acta,2003,1653(1):25-40.
5MEYER P,SERGI C,GARBE C.Polymorphisms of the BRAF gene predispose males to malignant melanoma[J].J Carcinog,2003,2(1):7-11.
6WOJNOWSKI L,STANCATO L F,LARNER A C,et al.Overlapping and specific functions of B-raf and C-raf-1 proto-oncogenes during mouse embryogenesis[J].Mech Dev,2000,91(1):97-104.
7HUSER M,LUCKETT J,CHILOECHES A,et al.MEK kinase activity is not necessary for Raf-1 function[J].EMBO J,2001,20(8):1940-1951.
8MIKULA M,SCHREIBER M,HUSAK Z,et al.Embryonic lethality and fetal liver apoptosis in mice lacking the C-raf-1 gene[J].EMRO J,2001,20(8):1952-1962.
9ZHANG B H,GUAN K L.Activation of B-raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601[J].EMRO J,2000,19(20):5429-5439.
10BONNI A,BRUNET A,WEST A E,et al.Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and-independent mechanisms[J].Science,1999,286(5443):1358-1362.