摘要
目的研究survivin在大肠癌组织中的表达及其与p53和bcl-2表达的关系。方法应用免疫组织化学SP法检测survivin,p53和bcl-2基因在32例大肠癌组织中的表达。结果survivin基因在32例大肠癌组织中,20例表达阳性,占62.5%;survivin基因表达与肿瘤部位和病理分级无明显相关性;大肠癌组织中p53基因阳性和阴性表达者中survivin基因表达阳性率分别为78.9%(15/19)及38.5%(5/13)两者比较,差异有显著性;bcl-2基因表达阳性和阴性者中survivin基因表达阳性率分别为70.6%(12/17)和53.3%(8/15)两者比较,差异无显著性。结论survivin基因在大肠癌组织中存在异常表达,与p53基因的异常表达密切相关,它可能参与了大肠癌的发生与发展。
Objective To study the expression of survivin gene in colorectal cancer and its relationship with the expression of p53 and bcl-2 gene. Methods Streptavidin biotin peroxidase（SP） method was used. The expression of survivin, p53, bcl-2 genes were examined in 32 cases of colorectal cancers. Results Survivin gene expressed in 20 of 32 cases of colorectal cancers. Overexpression of survivin was not related to tumor location and histologic differentiation. Expression of survivin segregated with p53 positive tumors as compared with p53 negative cases （ 15 of 19,78.9 % versus 5 of 13,38.5 % ） with statistical significance. In contrast, survivin gene expression did not correlate with bcl-2 normalities （12 of 17,70.6 % versus 8 of 15,53.3 % ）. Conclusion The abnormal expression of survivin gene suggests that survivin may play a role in onset and prcgression of colorectal cancer.
出处
《山西医科大学学报》
CAS
2006年第3期240-241,共2页
Journal of Shanxi Medical University
基金
深圳市龙岗区科学技术和信息局科研基金资助项目(2005-16)
