摘要
乙酰丹酚酸Ａ（ＡＳＡＡＡＳ）是丹参有效成分的衍生物。用三氯化铁局部涂抹损伤血管形成大鼠大脑中动脉血栓模型。以脑梗塞范围、行为障碍、脑组织病理改变为观察指标，研究ＡＳＡＡ对大脑中动脉血栓所致局部脑缺血的预防作用。结果表明，ＡＳＡＡ５０及１００ｍｇ·ｋｇ￣（１）ｉｖ可显著降低大鼠脑梗塞范围，改善行为障碍。脑组织检查中，ＡＳＡＡ１００ｍｇ·ｋｇ－１组动物大脑中动脉内血栓形成极少或未形成，脑组织缺血病变较轻。以上结果提示，ＡＳＡＡ可能通过抑制脑血栓形成，从而减轻血栓形成所致的局部脑缺血性损伤。
Acetylsalvianolic acid A(ASAA)is a semisynthetic analogue of salvianolic acid A isolated from Danshen(Salvia miltiorrhiza Bunge).Arat middle cerebral artery thrombesis medel wasmade by adding FeCl3 to the surface of the right middle cerebral artery(MCA).Using this medel,theprotective effects of ASAA on focal cerebral ischemic injury were studied.The neurologic status ofeach rat was carefully evaluated at 4,8 and 24 h after surgery.The cerebral infarction and themorphological changes of brain tissue were examined.Pretreatment with ASAA 50 or 100 mg· kg-1iv was shown to significantly reduce the cerebral infarction and attenuate neurological deficits,Thedegree of inhibition of cerebral infarction were 46.5%(P<0.65)and 87.4%(P<0.01),respectively.In pathological examination,pretreatment with ASAA 100 mg·kg-1 iv,there was nothrombosis or only a little thrombosis in MCA,The extent of tissue ischemia was much less than thatof control.These results indicate th8t the beneficial effects of ASAA on focal cerebral ischemic rats subjected to middle cerebral artery thrombosis may be related to its antithrombotic effect。
出处
《药学学报》
CAS
CSCD
北大核心
1996年第1期6-9,共4页
Acta Pharmaceutica Sinica
关键词
乙酰丹酚酸A
脑缺血
脑动脉血栓
Model of middle cerebral artery thrombosis:Focal cerebral ischemia:Salvianolic acid
Salvia miltiorrhiza
