摘要
我们采用从小牛肝中研制的肝细胞刺激物质（ＨＳＳ）对ＣＣＬ４损伤肝硬化大鼠进行长期治疗从细胞到整体水平探讨肝细胞增殖动力学变化情况，了解ＨＳＳ有无致畸、致癌作用。结果表明ＨＳＳ①刺激受损肝细胞ＤＮＡ增生；②增殖的肝细胞循环周期以Ｇ０／１期为主；③细胞倍体变化以４．８倍等整倍体细胞为主，未见异常倍体细胞。我们的实验结果没有发现ＨＳＳ促进受损肝细胞畸变作用。
Hepatic stimulating substances were prepared from livers of calf and with it to treat CCl4─induced chronic liver damage. The kinetic of liver cells were observed. Our aim is going to go further into whether the use of HSS lead to liver cells deformity or carcinogensis.Results indicated: (1)the DNA corporation with 3H-TdR of liver parachymal cells in HSStreated increased respectively as compared with control rats (P<0. 01); (2)the proportion of proliferation cells of HSS-treated groups were mainly G0/1; (3) the ploydies of HSS-treated were mainly consisted of four,eignt ploids,and abnormal distributetion ploydies hadn' t been found.
出处
《临床肝胆病杂志》
CAS
1996年第1期11-13,共3页
Journal of Clinical Hepatology
