摘要
目的:研究花刺参体内的化学成分。方法:应用Sephadex LH-20,正相硅胶柱层析、反相硅胶柱层析和HPLC对花刺参体内化学成分进行分离纯化,根据化合物的理化性质和波谱数据鉴定其结构。结果:分离并鉴定了2个三萜皂苷类化合物:3-O-[3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→3)-β-D-吡喃葡萄糖-(1→2)-β-D-吡喃木糖]-海参烷-7-烯-3β,23S-二醇(Ⅰ),3-O-[3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→3)-β-D-吡喃葡萄糖-(1→2)-β-D-吡喃木糖]-海参烷-8-烯-3β,23S-二醇(Ⅱ)。结论:2个化合物均为新化合物,命名为variegatuside A和variegatuside B。
AIM： To study the constituents from the sea cucumber Stichopus variegatus Semper. METHOD： Triterpene glycosides from Stichopus variegatus Semper were separated and purified by silica gel chromatography, reversed-phase silica gel chromatography and reversed-phase HPLC. Their structures were elucidated on the basis of chemical evidence and spectral data. RESULTS： Two new triterpenes were isolated and their chemical structures were established as 3-O-[3-O-methyl-β-D-glucopyranosyl-（1→ 3）-β-D- xylopyranosyl-（ 1→3 ）-β-D-glucopyranosyl-（ 1 → 2 ）-β-D-xylopyranosyl ]-holosta-7-ene-3β, 23S-diol; 3-O-[ 3-O-methyl-β-D- glucopyranosyl- （ 1→ 3 ） -β- D-xylopyranosyl- （ 1→ 3 ）-β- D-glucopyranosyl- （ 1 →2 ）-β- D-xylopyranosyl ] -holosta-8-ene-3β, 23 S-diol. CONCLUSION： The glycosides are both new compounds, which are named variegatuside A and B.
出处
《中国天然药物》
SCIE
CAS
CSCD
2006年第3期176-180,共5页
基金
国家高技术研究发展计划("863"计划)(NO.2001AA624100)~~
关键词
花刺参
海参
三萜皂苷
This project was supported by National High Technology Development Project（ NO. 2001AA624100）.
