摘要
3,5-双三氟甲基苯甲酸[CAS:725-89-3]的合成是先通过1,3-二溴-5,5-二甲基乙内酰脲,与1,3-双三氟甲基苯生成3,5-双三氟甲基溴苯,收率98%,选择性99%。然后由3,5-双三氟甲基溴苯作原料来合成3,5-双三氟甲基苯甲酸,收率72%以上。本文讨论了不同反应摩尔比,反应温度等条件,并得到最优化条件。
The 1,Br-3,5-bis- （trifluormethyl）-benzene was prep. Using of 1,3-diBromo-5.5-dimethyl-imidazolidine-2,4-dione and 1,3-his- （trifluoromethyl）-benzene as material, was synthesized in sulphuric acid.The yield of 98%,the select of 99% 3,5-bis-（trifluoromethyl）-benzoic acid[CAS：725-89-3] was prep,using of The 1, Br-3,5-bis- （trifluormethyl）-benzene as material, was synthesized in sulphuric acid the yield of 72%.The influene factors such as molar ratio of material reactiom tempereture catalyst and time was studied. The best reaction was obtained.
