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红豆杉细胞的工业化培养 被引量:4

The Cell Industrialization Culture of Taxus
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摘要 介绍了近年来红豆杉细胞工业化培养生产紫杉醇的研究进展。重点介绍了添加诱导子、剪切力和溶解氧对紫杉醇产量的影响,以及利用生物反应器进行细胞培养时所存在的问题,为探索生产紫杉醇的最适条件和大规模细胞培养提供了理论依据。 The recent progress in the research on production of taxol by taxus cell industrialization culture was reviewed. Effects of addition of elicitors, shear stress and dissolved O2 tension on taxol production and the problems in cell culture by using the bioreactor were reviewed emphatically. The theoretical envidcnce was provided for optimal conditions of producing taxol and cell culture in a large scale.
出处 《时珍国医国药》 CAS CSCD 北大核心 2006年第5期844-846,共3页 Lishizhen Medicine and Materia Medica Research
关键词 红豆杉 紫杉醇 生物反应器 Taxus chinensis Taxol Bioreactor
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  • 1Francis AL. Plant cell culture doesn't require a green thumbjust the right reagents [J]. The Scientist - Pharmers Market, 2000,14:9.
  • 2常钰,刘涤,胡之璧.植物细胞和器官大规模培养研究的进展[J].生物技术通报,2001,17(1):31-36. 被引量:40
  • 3张泓.植物培养细胞的形态分化与次生代谢产物的生产[J].植物学通报,1994,11(1):12-19. 被引量:32
  • 4Xu J F, Yin P Q, Wei X G,. Self - immobilized aggregate culture of Taxus cuspidate for improved taxol production - callus culture for taxol preparation used as a cytostatic agent [J]. Biotechnology, 1998, 12(3): 241.
  • 5Yukimune H, Matsubara K. Hara Y. Producing taxan - type diterpenes e.g. taxol, useful as therapeutic agents in cancer treatment. EP- 887-419, 1999.
  • 6戴均贵,陈永勤,朱蔚华.几种红豆杉属植物不定根的形成及其紫杉醇的产生[J].植物生理学通讯,2000,36(1):14-18. 被引量:2
  • 7Wann, Steven R. Method for preoduction of plant biological products in precocious nemorphiic embtyosis[J]. US Patent NO 238018, 1994.
  • 8Qian ZG, Zhao ZJ, Xu Y, et al. Highly efficient strategy for enhancing taxoid production by repeated elicitation with a newly synthesized jasmonate in fed - batch cultivation of Taxus chinensis cell [J]. Biotechnology and Bioengineering,2005, 90(4):516.
  • 9Pan Z, Wang H, Zhong J. Scale - up study on suspension cultures of Taxus chinensis cell for production of taxane diterpene [J]. Enzymeand Microbial Technology, 2000,27(9):714.
  • 10Zhen - Yun Wang, Jian - Jiang Zhong. Combination of conditioned medium and elieitation enhances taxoid production in bioreactor cultures of Taxus chinensis cells [J]. Biochemical Engineering Journal, 2002,12:93.

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