摘要
目的探讨超声检查所发现的甲状腺结节钙化与甲状腺良恶性病变的关系。方法收集3年间我院收治的、术前行高分辨彩色二维超声检查并经手术和石蜡病理确诊的1 0 7例甲状腺恶性结节和7 0 3例良性结节患者的检查资料,回顾性分析其超声报告中钙化和沙粒样钙化,在良、恶性病变,和不同性别、年龄组中所占比例。结果钙化和沙粒样钙化在甲状腺良、恶性病变间分别为6 3.5 5%,2 9.0 2%和2 4.3%,1.9 9%,差异有极显著性(P<0.0 0 1);在男女组间分别为3 1.9 3%,3 4.0 1%和5.4 2%,4.8 1%,差异无显著性(P>0.0 5)。钙化在不同年龄组分别为3 0.7 3%和36.90%,差异无显著性(P>0.0 5);而沙粒样钙化在不同年龄组间分别为7.7 5%和2.5 2%,差异有极显著性(P<0.0 0 1),在<4 5岁年龄组中灵敏度明显增高。结论对超声检查发现甲状腺结节钙化的患者,应提高警惕,以排除恶性病变;以沙粒样钙化预测甲状腺癌的特异性极高。
Objective To investigate the calcification of thyroid nodule detected on ultrasound and the relation with benign and malignant disease. Methods Data of 107 cases of malignant and 703 cases of benign thyroid nodules examined by high-resolution colored uhrasonography preoperatively and pathological diagnosis by paraffin embedded slides postoperatively were collected from our hospital over a period of 3 years. The percentages of calcification and fine stippled psammomatous （FSP） calcification in benign and malignant nodular disease, in different sexes and different age groups were retrospectively reviewed. Results The incidences of calcification and FSP calcification were significantly higher in malignant group （ 63. 55 % , 29.02% , respectively ） than in benign group （ P 〈 0. 001 ）. There was no significant difference between male and female groups （ 24. 3% , 1. 99% , respectively ） （ P 〉 0. 05 ） . Calcification rate showed no significant difference between different age groups （ 〈 45 and ≥45 ） （ P 〉 0.05 ） ; however, there was a significant difference of the FSP calcification rate between different age groups （ P 〈 0. 001 ）. The sensitivity of malignancy diagnosis was significantly higher in the group of patients younger than 45 years of age with FSP calcification of thyroid nodule. Conclusions When calcification is noted on ultrasonography, it should raise the clinical index of suspicion for malignancy. FSP Calcification is a very highly specific in prediction of thyroid malignancy.
出处
《中国普通外科杂志》
CAS
CSCD
2006年第4期267-270,共4页
China Journal of General Surgery
