摘要
目的探讨血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平与新生儿感染之间的关系。方法采用酶联免疫吸附试验(ELISA)和免疫比浊法检测45例新生儿感染患儿及20例正常健康儿血清中IL-6I、L-8和C-反应蛋白(CRP)的含量。结果新生儿感染急性期IL-6、IL-8和CRP水平较对照组明显升高(P<0.001),败血症组较非败血症组明显升高(P<0.001),恢复期与正常水平差异无显著性(P>0.05);感染急性期IL-6、IL-8和CRP水平呈正相关性(P<0.01)。结论IL-6、IL-8参与了炎症反应过程,其水平的高低可反映疾病的严重程度,可作为感染性疾病早期诊断的重要检测指标。
Objective To explore the clinical significance of IL- 6 and IL- 8 in neonatal infection. Methotis The serum levels of IL - 6, IL - 8 and C - reactive protein （ CRP ） were detected by ELISA and Immunity in 45 neonates with infection and in 20 healthy controls. Results The serum IL - 6 , IL - 8 and CRP levels in neonates with infection at the acute period of disease were significantly higher than those in controls（ P 〈 0.001 ） ; serum IL - 6 , IL - 8 and CRP levels in neonates with sepsis group were significantly higher than those in nonsepsis group （ P 〈 0.001） . No difference of those results were found between newboms in infectious recovery peri- od and control group（ P 〉 0.05 ）. Serum IL - 6 , IL - 8 had positive correlation with CRP in acute period of dis- ease（ P 〈 0.01 ）. Conclusion The IL - 6, IL - 8 are involved in neonate infection , and had correlation with degree of infection. Inflammatory cytokines might be sensitive markers of diagnosis for neonatal infection.
出处
《南华大学学报（医学版）》
2006年第1期92-93,137,共3页
Journal of Nanhua University(Medical Edition)
