摘要
目的分析前列腺癌三维适形放疗的疗效及预后因素。方法对37例前列腺癌患者进行三维适形放疗,24例行三维适形放疗前接受双侧睾丸切除,4例行放疗去势。20例同时服用艾去适内分泌化疗药物9～12个月。采用三维适形放疗技术照射前列腺靶区,5次/周,2Gy/次。肿瘤中位剂量72Gy(60～76Gy)。用Longrank进行单因素,Cox进行多因素分析。结果中位随访27个月(6～107个月),随访率为95%。3、5年生存率分别为80%、70%。单因素分析显示年龄、治疗前PSA水平、有无区域淋巴结转移、是否合并远处转移、靶区照射剂量及是否采用综合治疗对生存期有影响。多因素分析显示治疗前PSA水平、靶区照射剂量及是否采取综合治疗3个因素影响预后。结论前列腺癌三维适形放疗安全有效,治疗前PSA水平、靶区照射剂量及是否采取综合治疗是预后的影响因素。
Objective To evaluate the outcome and prognosis of prostate carcinoma treated with three-dimensional conformal radiation therapy（3DCRT）. Methods From 2000 to 2004,37 patients were so treated. Two patients have been lost to follow up. Twenty-four patients underwent orchiectomy before 3DCRT, 20 patients received chemotherapy combined with hormone therapy and 4 received radiation castration. All patients were treated with a median dose of 72 Gy（60-76 Gy） ,2 Gy/f ,5 fractions/w. Results With a median follow-up time of 27 months（6-107months）, the 3- and 5-year survival rate was 80% and 70%, respectively. Longrank analysis showed age, PSA level before treatment, lymph node metastasis, distant metastasis, total dose and combined modality were prognostic factors for the survival. Cox model multivariate analysis showed PSA level before treatment, total dose and combined modality were prognostic factors for the survival. Conclusions The outcome of three-dimensional conformal radiation therapy for T2-T4 prostate carcinoma is safe and effective with tolerable side effects. PSA level before treatment, total dose and combined modality are prognostic factors for the survival.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2006年第3期201-203,共3页
Chinese Journal of Radiation Oncology
关键词
前列腺肿瘤/放射疗法
三维适形
预后
Prostate neoplasms/radiotherapy
Three-dimensional conformal
Prognosis
