摘要
组织工程心脏瓣膜是一种具有活力、能够自我修复和增生的人工瓣膜。理想的组织工程心脏瓣膜由于具有优良的血流动力学特征,低或甚至无免疫反应,不需要长期抗凝治疗以及耐用性好等特性,能够很好地克服目前临床上使用的机械瓣和生物瓣的缺点。综述了近年来国外组织工程心脏瓣膜在生物材料、培养环境和种子细胞等方面的新进展,并展望了干细胞作为种子细胞的应用前景。
The tissue engineering heart valve （TEHV） is a kind of procthetic valve that possesses the characteristics of living, self-repair and proliferation. Owing to the specific properties that are the better hemodynamics, low or even no immunological reaction, no need for long-time anticoagulation therapy and longer durability, the ideal TEHV can overcome the drawback of current available valve substitutes which are mechanical prostheses and biological heart valves. In this paper we reviewed the recent development of the TEHV in such aspects, as biomaterial, cultivating environment, seed ceils and so on. In addition, we briefly introduced the perspective of using human embryonic stem ceils as the source for seed cells in TEHV.
出处
《国际生物医学工程杂志》
CAS
2006年第2期110-113,共4页
International Journal of Biomedical Engineering
关键词
组织工程
心脏瓣膜
核移植
种子细胞
tissue engineering
heart valve prostbesis
nuclear transfer
seed cells
