摘要
目的观察肝病患者血清肉碱水平,探讨其临床意义,为肉碱治疗肝病提供依据。方法用酶循环法检测25例急性病毒性肝炎,34例慢性病毒性肝炎,22例肾功能正常及9例肾功能异常的肝炎后肝硬化患者血清游离肉碱水平,并分别与40名正常人的检测值比较。结果血清游离肉碱:正常人为(48．3±10．2)μmol／L;急性病毒性肝炎患者为(35．2±13．2)μmol／L,明显低于正常对照组,P=0．000。慢性病毒性肝炎患者为(36．5±9．9) μmol／L,明显低于正常对照组,P=0．000。肾功能正常的肝炎后肝硬化患者为(45．0±11．0)μmol／L,比正常对照组略有下降,但差异无统计学意义,P=0．232。肾功能异常的肝炎后肝硬化患者为(83．6±50.4)μmol／L,比正常对照组升高,但差异无统计学意义,P=0．069。结论肝病患者可发生肉碱代谢异常,肝脏疾病是导致继发性肉碱缺乏的原因之一。
Objective To determine serum carnitine levels in patients with liver diseases and to investigate their significance. Methods 25 patients with acute viral hepatitis, 34 with chronic viral hepatitis, 22 with post hepatitis cirrhosis with normal renal function, 9 with post hepatitis cirrhosis but with renal disfunction, and 40 healthy subjects （serving as controls） were enrolled in this study. An enzymatic cycling method was used.to determine the serum free carnitine levels. Results The serum free camitine level was （48.3 ± 10.2） μmol/L in the healthy control group. It was （35.2 ± 13.2） μmol/L in the acute viral hepa- titis group, （36.5 ± 9.9） μmol/L in the chronic viral hepatitis group, （45.0 ± 11.0） vmol/L in the post hepatitis cirrhosis with normal renal function group, and （83.6 ± 50.4）μmol/L in the post hepatitis cirrhosis with renal dysfunction group. Serum free carnitine levels in the acute viral hepatitis and chronic viral hepatitis groups were significantly lower than those in the healthy controls. There were no significant differences in serum free carnitine levels of the post hepatitis cirrhosis group and the normal control group. Condusions Patients with liver diseases can have carnitine metabolism errors. One of the secondary carnitine lack causes is liver disease.
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2006年第5期367-369,共3页
Chinese Journal of Hepatology
关键词
肝疾病
肉碱
研究
Liver diseases
Carnitine
Research
