摘要
目的观察含大蒜素胶囊的PP I三联及四联疗法对幽门螺杆菌(HP)阳性十二指肠溃疡的疗效。方法92例HP阳性的十二指肠溃疡患者随机分为3组,A组为治疗1组31例,口服奥美拉唑+克拉霉素+大蒜素胶囊治疗;B组为治疗2组31例,口服奥美拉唑+克拉霉素+痢特灵+大蒜素胶囊治疗;C组为对照组30例,口服奥美拉唑+克拉霉素+痢特灵治疗。疗程均为7天。7天后,3组均继续服用3周奥美拉唑。停药4周后复查胃镜、快速尿素酶试验与14C尿素呼气试验,评估HP根除率及溃疡愈合率。结果HP根除率以意向治疗分析(ITT)和完成治疗分析(pp)表示。92例病人均可纳入ITT分析。A、B、C组的ITT分别为83.87、90.32和83.33%;PP分别为86.67、93.33和86.21%。B组HP根除率比C组稍高,但3组间HP根除率比较差异无统计学意义(P>0.05)。A、B、C组十二指肠溃疡的愈合率ITT及PP分别是93.55、96.67、96.77%及100.00、93.33、96.55%,各组间差异无统计学意义(P>0.05)。不良反应发生率差异亦无统计学意义(P>0.05),普遍均能耐受。结论含大蒜素胶囊的PP I三联、四联疗法1周治疗均能有效根除十二指肠溃疡病人的HP感染,治愈球部溃疡。虽HP根除率和溃疡愈合率与低剂量克拉霉素基础PP I疗法相当,无明显不良反应,但四联更为理想。
Objective To evaluate the efficacy, side effects of triple and quadruple therapy containing garlicin on eradicating Helicobacter pylori（HP） and curing duodenal ulcer. Methods 92 patients with HP-positive duodenal ulcer were randomized allocated to three groups. Group A （n=31） received omeprazole （20mg, twice daily）, clarithromycln （250mg, twice daily）and garlicin （40mg three times daily） for 1 week. Group B （n= 31） received furazolidone （100rag, twice daily for 1 week） in addition to the same close of medication as Group A. Group C （n=30） received the same close of omeprazole, clarithromycin, and furazolldone but without garlicin. Omeprazole was continually administered to each group for three weeks after one week of above-mentloned medication. Endoscopy was carried out 4 weeks after completion of the therapy to assess the ulcer healing and HP eradication, Results The eradication rate of HP and ulcer healing rate in Groups A, B, and C were 26（83.87%） and 29（93.55）, 28（90.32%） and 30（96.67%）, 25（83.33%） and 28（93.33%） respectively. There was no statistical significance in terms of efficacy and side effects among groups （P：〉 0. 05）. Conclusion Despite similar efficacy in HP eradication and duodenal ulcer healing rate, the quadruple therapy with garlicin is safer and more effective than triple therapy.
出处
《西部医学》
2006年第3期304-306,共3页
Medical Journal of West China
