摘要
目的探讨重度子癎前期患者血清中抗中性粒细胞胞浆抗体(antineutrophil cytoplas- mic autoantibodies,ANCA)两种主要靶抗原蛋白酶3(protein3,PR3)和髓过氧化物酶(myeloperoxi- dase,MPO)的表达与子癎前期发病的关系。方法用抗原特异性酶联免疫吸附法(ELISA)测定 31例重度子癎前期和31例同期正常孕妇(对照组)血清中的PR3和MPO。结果 (1)重度子癎 前期组PR3(+)者占25．8％(8／31),高于对照组的9．7％(3／31),但两组比较无统计学差异(X2= 2．763,P>0．05);重度子癎前期组MPO(+)占25．8％(8／31),对照组占19．4％(6／31),两组比较无统计学差异(X2=0．369,P>0．05)。(2)重度子癎前期组ANCA(+)者和ANCA(一)者比较各母儿并发症发生率无统计学差异,但肾功能不全患者共4例均发生于ANCA(+)者。结论 ANCA 可能与子癎前期的肾脏病变有关,是否参与子癎前期的发病机制还有待于进一步研究。
Objective To discuss the expression of two primary target antigens protein 3（PR3） and myeloperoxidase （MPO） of serum antineutrophil cytoplasmic autoantibodies（ANCA）and its relationship with the onset of preeclampsia. Methods Serum PR3 and MPO expression was detected with antigen specific ELISA in 31 severe preeclampsia（S-PE） women and 31 normal pregnant women （control） . Results The PR3 positive rate（8/31） in S-PE group was higher than that of the control （3/31） without statistic significance（25.8% vs 9. 7%, P〉0.05） and the same with the MPO positive rate（25.8% vs 19.4%, P〉0.05）. No significant difference was found in maternal and neonatal complications between the ANCA（＋） and ANCA（- ） subgroups in S-PE subjects. But those 4 cases who developed renal function insufficiency patients were ANCA（＋）. Conclusions ANCA might be associated with renal diseases in preeclampsia women, and further studies is required to determine whether ANCA is involved with the pathogenesis of preeclampsia.
出处
《中华围产医学杂志》
CAS
2006年第2期100-102,共3页
Chinese Journal of Perinatal Medicine
