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纤溶酶原激活物抑制剂-1在肝纤维化中的作用

Role of plasminogen activator inhibitor-1 in hepatic fibrosis
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作者 朱颖炜 林勇 谢渭芬
机构地区 上海第二军医大学长征医院消化内科
出处 《肝脏》 2006年第2期133-134,共2页 Chinese Hepatology
基金 2005上海市青年科技启明星跟踪计划(05QM1+1406)
关键词 纤溶酶原激活物抑制剂-1 肝纤维化 细胞外基质(ECM) 尿激酶型纤溶酶原激活物 纤维蛋白溶解系统 基质金属蛋白酶 纤维化疾病 PAI-1 修复反应 慢性损伤
分类号 R575.2 [医药卫生—消化系统]
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参考文献17

  • 1Kutz SM,Nikey SAT,White LA,et al.Induced PAI-1 mRNA expression and targeted protein accumulation are early G1 events in serum-stimulated rat kidney cells.J Cell Physiol,1997,170:8-18.
  • 2Tsuyoshi O,Michael F,Wilbur L,et al.Modulation of plasminogen activator inhibitor-1 in vivo:A new mechanism for the anti-fibrotic effect of rennin-angiotensin inhibitor.Kindey Int,1997,51:164-172.
  • 3Rieder H,Armbrust T,Meyer zum Buschenfelde KH,et al.Contribution of sinusoidal endothelial liver cells to liver fibrosis:expression of transforming growth factor-beta 1 receptors and modulation of plasmin-generating by transforming growth factor-beta 1.Hepatology,1993,18:937-944.
  • 4Zhang LP,Takahara T,Yata Y,et al.Increased expression of plasminogen activator and plasminogen activator inhibitor during liver fibrogenesis of rats:role of stellate cells.J Hepatol,1999,31:703-711.
  • 5Leyland H,Gentry J,Arthur MJP,et al.The plasminogen-activating system in hepatic stellate cells.Hepatology,1996,24:1172-1178.
  • 6Inuzuka S,Ueno T,Torimura T,et al.The significance of colocalization of plasminogen activator inhibitor-1 and vitornectin in hepatic fibrosis.Scand J Ganstrenterol,1997,32:1052-1060.
  • 7Kamada Y,Tamura S,Kiso S,et al.Angiotensin Ⅱ stimulates the nuclear translocation of Smad2 and induces PAI-1 mRNA in rat hepatic stellate cells.Hepatol Res,2003,25:296-305.
  • 8Seki T,Imai H,Uno S,et al.Production of tissue-type plasminogen activator(t-PA) and type-1 plasminogen activator inhibitor (PAI-1) in mildly cirrhotic rat liver.Thromb Haemost,1996,75:801-807.
  • 9武希润,吕敏和,王琦,师水生,郭文栋.α-平滑肌肌动蛋白表达及血浆转化生长因子β_1变化在肝纤维化发生发展中的作用[J].中华肝脏病杂志,2004,12(7):400-402. 被引量：21
  • 10武希润,王琦,师水生,吕敏和,郭文栋.肝硬化患者血浆中尿激酶型纤溶酶激活物的检测及其意义[J].中华肝脏病杂志,2004,12(2):82-84. 被引量：13

二级参考文献13

  • 1Hayasaka A, Saisho H. Serum markers as tools to monitor liver fibrosis. Digestion, 1998, 59: 381-384.
  • 2Rockey DC. The cell and molecular biology of hepatic fibrogenesis. Clinical and therapeutic implication. Clin Liver Dis, 2000, 4: 319-355.
  • 3Salgado S, Garcia J, Vera J, et al. Liver cirrhosis is reverted by urokinase-type plasminogen activator gene therapy. Mol Ther, 2000, 2: 545-551.
  • 4Bezerra JA, Bugge TH, Melin-Aldana H, et al. Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver. Proc Natl Acad Sci, 1999, 96: 15143-15148.
  • 5Zhang LP, Takahara T, Yata Y, et al. Increased expression of plasminogen activator and plasminogen activator inhibitor during liver fibrogenesis of rats: role of stellate cells. J Hepatol, 1999, 31: 703-711.
  • 6Zhang LP,Takahara T,Yata Y,et al.Increased expression of plasminogen activator and plasinogen activator inhibitor during liver fibrogensis of rats: role of satellite cells[].Journal of Hepatology.1999
  • 7Salgado S,Garcia J,Vera J,et al.Liver cirrhosis is reverted by urokinase-type plasminogen activator gene therapy[].Molecular Therapy.2000
  • 8Leyland H,Gentry J,Arthur M J,et al.The plasminogen-activating system in hepatic stellate cells[].Hepatology.1996
  • 9Okuno M,Akita K,Moriwaki H,et al.Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta[].Gastroenterology.2001
  • 10Bezerra JA,Currier AR,Melin Aldana H,et al.Plasminogen activators direct recorganization of the liver lobule after acute injury[].American Journal of Pathology.2001

共引文献30

肝脏
2006年 第2期

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