摘要
目的探讨毛细血管内增生性肾小球肾炎并发肾病综合征的临床病理特点与发病机制。方法12例患者肾穿刺术后,标本经常规固定、包埋、切片,进行HE、六胺银、Masson和免疫荧光染色,其中3例予以电镜观察。结果肾小球系膜细胞、内皮细胞增生;小球内可见中性多核白细胞渗出。10例毛细血管襻和(或)灶性系膜区有免疫复合物沉积。3例上皮细胞足突融合消失,上皮下电子致密物沉积。结论EPGN发生大量蛋白尿的机制与肾小球滤过膜状态的改变关系密切,使其对蛋白的通透性大大增加。
Objective： To investigate the clinical and pathological characteristies of endoeapillary proliferative glomerolonephritis （EPGN） with nephritic syndrome （NS） and mechanism of it. Methods： Specimens from renal biopsies of 12 EPGN with NS were performed to examine lesions by HE, PASM, Masson, and immunofluorescin staining. Results： The glomeruli are distended by the proliferation and edema of mesangial, endothelial cells, together with a variable infiltration of polymorphonuclear leukoeytes. Immunofluoreseenee reveals deposition of immune complex in renal capillary tufts or focal areas of mesangiurn in 10 cases. Uhrastructural microscopy feature is characterized by subepithelial electron - dense deposits and the loss of epithelial foot processes in 3 eases. Conclusions： The paal and physiological changes result in the increasing permeability of glomeralar wall, and there maybe a relative correlation between the mechanism and the state changes of the glomerular filtering membrane of EPGN with large proteinuria.
出处
《华西医学》
CAS
2006年第2期290-291,共2页
West China Medical Journal
关键词
毛细血管内增生性肾小球肾炎
肾病综合征
肾活检
Endcocapillary proliferative glomerulonephritis
Nephritic syndrome
Renal biopsy
