摘要
Started from the liver targeting compounds（glycyrrhizin,glycyrrhetinicacid,bile acid）,six（amine-terminated） compounds were prepared via two-step reactions.The NMR experiments provided the direct evidence of the existence of amide.The polymers were synthesized by polymerizing of BLG-NCA initiated by each of six amine-terminated compounds.The liver targeting group was introduced to the main chain of the polymer.The molecular weight of the resultant polymers was adjusted by changing the molar ratio of monomer BLG-NCA to initiator.The product structure was characterized by GPC,FTIR and（）1H NMR.The results demonstrate that amine-terminated compounds containing liver targeting group could initiate the polymerization of BLG-NCA.
Started from the liver amine-terminated compounds were p targeting compounds （ glycyrrhizin, glycyrrhetinicacid, bile acid ）, six repared via two-step reactions. The NMR experiments provided the direct evidence of the existence of amide. The polymers were synthesized by polymerizing of BLG-NCA initiated by each of six amine-terminated compounds. The liver targeting group was introduced to the main chain of the polymer. The molecular weight of the resultant polymers was adjusted by changing the molar ratio of monomer BLG-NCA to initiator. The product structure was characterized by GPC, FTIR and ^1H NMR. The results demonstrate that amine-terminated compounds containing liver targeting group could initiate the polymerization of BLG-NCA.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2006年第5期885-887,共3页
Chemical Journal of Chinese Universities
基金
教育部天津大学-南开大学科技合作基金资助
关键词
肝靶向
甘草酸
甘草次酸
胆酸
聚谷氨酸苄酯
Target of liver
Glycyrrhizin
Glycyrrhetinic acid
Bile acid
Poly（γ-benzyl-L-glutamate）
