摘要
目的 探讨子宫内膜浆液性乳头状癌（uterine papillary serous carcinoma，UPSC）的临床病理特征，以及合理的治疗方法。方法 对2000年1月～2004年12月我院收治的34例UPSC进行回顾性研究，对其发病趋势、危险因素、临床表现、病理特征、目前诊断方法和治疗方案进行统计学分析。结果 Ⅲ、Ⅳ期患者占44．1％，深肌层及以上浸润者占70．6％。64．7％患者术后病理分期高于术前临床分期。91．2％患者雌孕激素受体阴性。全部患者手术治疗，绝大部分术后辅以化疗、放疗，生存率较以往文献提高，但仍较其他类型子宫内膜癌差。结论 UPSC不同于其他类型子宫内膜癌，其特殊的生物学行为和病理特征决定UPSC具有高度恶性表现。随着对其逐步认识，目前诊断和治疗均较以往有较大提高。
Objective To investigate the clinical and pathologic characteristics, and study the rational therapy for uterine papillary serous carcinoma （UPSC）. Methods A retrospective study was conducted on incidence, risk factors, clinical charactefisties, pathological feature, diagnosis and treatment of 34 patients with UPSC, who was admitted in our hospital from Jan 2000 to Dec 2004. Results Amongall the patients with UPSC, 44.1% was stage Ⅲ and Ⅳ; 70.6 % with deep myometrial invasion; 64.7 % diagnosed as higher stage postoperatively than preoperative staging; and 91.2% presented negative estrogen or progestin receptor. All the patients underwent operation, and a great part received postoperative radiotherapy and/or chemotherapy. The survival rate was obviously higher than previous reports, but still lower than other types of endometrial carcinoma. Conclusions UPSC is highly malignant, which has different clinical and pathologic characteristics from the common endometrial adenocarcinoma. The diagnosis and treatment of UPSC are improving as we know better about it.
出处
《中国妇产科临床杂志》
2006年第3期170-173,204,共5页
Chinese Journal of Clinical Obstetrics and Gynecology
关键词
子宫内膜浆液性乳头状癌
非激素依赖
临床病理
治疗
uterine papillary serous carcinoma
estrogen- independent
clinical- pathology
treatment
