摘要
白细胞介素-18(IL-18)是一种炎症细胞因子,它可以促进Th1免疫反应,诱导T细胞增生并分泌大量的干扰素-γ。作为一种新的细胞因子,IL-18的产生和1型糖尿病密切相关。文中主要从1型糖尿病时IL-18表达水平的改变、IL-18在1型糖尿病发病机制中的作用、IL-18基因单核苷酸多态性与1型糖尿病的关系、阻止IL-18的表达与1型糖尿病的治疗方面介绍了IL-18与1型糖尿病相关的研究进展。
Interleukin-18 （IL-18） as a proinflammatory eytokine can promote Thl cell mediated immunal reactions, induce the proliferation of T cells and stimulate the secretion of interferon-γ. As a novel cytokine, interleukin-18 is closely related to type 1 diabetes mellitus. This paper introduces the advances in the study of interleukin-18 and type 1 diabetes, including the changes of serum IL-18 levels, the role of IL-18 in the pathogenesis of type 1 diabetes, the relation between IL-18 gene polymorphisms and type 1 diabetes and blocking the expression of IL-18 in treatment of type 1 diabetes.
出处
《国际内分泌代谢杂志》
2006年第3期170-172,共3页
International Journal of Endocrinology and Metabolism
