摘要
目的：探讨原发性闭角型青光眼患者的发病机理。方法：对４４例原发性闭角型青光眼患者和２５例正常人的血液流变学、血液中血栓素和前列腺素等指标进行了检测。结果：原发性闭角型青光眼患者的低切与高切全血比粘度、血浆粘度，血球压积、红细胞电泳、红细胞聚集指数、血栓素Ｂ２、β一血栓球蛋白、ｖＷＦ和Ｔ／Ｋ比值明显升高（Ｐ＜０．０５或Ｐ＜０．０１），６一ｋｅｔｏ一ＰＧＦ１α。明显降低，与正常组相比，均有显著性意义（Ｐ＜０．００１）。结论：原发性闭角型青光眼患者存在血液流变学异常，并有血管内皮细胞受损、血小板聚集性增强和血液呈现高凝状态的血瘀改变。
OBJECTIVE:To investigate the mechanism of primary angle-closure glaucoma.METHODS:the indexes of blood rheology,thromboxane and prostaglandin in the blood of 44 pa-tients with primary angle-closure glaucoma and 25 normal people were measured. RESULTS:The whole blood viscosity,index of erythrocyte aggregation,thremboxane B2,β-thrombusglobulins,vWF and T/K of the patients were significantly higher than those in normal controlgroup(P<0.05orP<0.01),6-keto-PGF1α were significantly lower(P<0.001).CONCLUSION:It is suggested that there exists abnormality of blood rheology for primary angle-closure glaucomapatient,and also a change of blood stasis,which results from the abnormal vascularendotheliocyte,increasement of platelet aggregation and hypercoagufability.
出处
《中国中医眼科杂志》
1996年第2期80-83,共4页
China Journal of Chinese Ophthalmology
基金
国家中医药管理局科研基金
关键词
闭角型
青光眼
血液流变学
血栓素
前列腺素
angle-clocure glaucoma
blood rheology
thromboxane
prostaglandin
bloodstasis
