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颅脑损伤并发中枢性低钠血症的临床分析 被引量:15

Clinical analysis of craniocerebral injury with central hyponatremia
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摘要 目的总结分析颅脑损伤并发中枢性低钠血症的临床特点。方法回顾性分析我科近14年收治的1 531例颅脑损伤病人血、尿电解质、渗透压等的检测结果。结果本组10例符合抗利尿激素分泌异常综合征,其中治愈8例,死亡2例;15例颅脑损伤符合脑性耗盐综合征,治愈13例,死亡2例。结论颅脑损伤并发抗利尿激素分泌异常综合征的发病机制与治疗措施不同于脑性耗盐综合征,对其进行早期诊治能降低颅脑损伤病人的致残率和死亡率。 Objective To study the clinical features of craniocerebral injury with central hyponatremia. Methods The plasma osmalality,plasma electrolyte content,urine osmalality and urine electrolyte content of 1 531 patients of craniocerebral injury in the past 14 years were analysed retrospectively. Results Syndrome of inappropilate antidiuretic hormone was found in 10 cases, with which 8 patients were cured and 2 patients died. Cerebral salt wasting syndrome were found in 15 cases,with which 13 patients were cured and 2 patients died. Conclusion Pathogenesis and management of syndrome of inappropriate antidiuretic hormone complicated with craniocerebral injury is different from that of cerebral salt wasting syndrome. Early diaglosis and therapy can reduce its morbidity and mortality.
出处 《创伤外科杂志》 2006年第1期22-24,共3页 Journal of Traumatic Surgery
关键词 颅脑损伤 低钠血症 抗利尿激素分泌异常综合征 脑性耗盐综合征 craniocerebral injury hyponatremia syndrome of inappropriate antidiuretic hormone cerebral salt wasting syndrome
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参考文献6

  • 1Van Amelsvoort T,Baskshi R,Devaux CB,et al.Hyponatraemia associated with carbamazepine and oxcarbamazepine therapy:a review[J].Epilepsia,1994,35(1):181-188.
  • 2Watabe R,Shibata K,Hirase N,et al.Angiotropic B-cell lymphoma with hemophagocytic syndrome associated with syndrome of inappropriate secretion of antidiuretic hormone[J].Ann Hematol,2000,79(10):581-584.
  • 3Zafonte RD,Mann NR.Cerebral salt wasting syndrome in brain injury patients:a potential cause of hyponatraemia[J].Arch Phys Med Rehabil,1997,78(5):540-542.
  • 4Damaraju SC,Rajshekhar V,Chandy MJ.Validation study of a central venous pressure-based protocol for the management of neurosurgical patients with hyponatremia and natriuresis[J].Neurosurgery,1997,40(2):312-317.
  • 5Berkenbosch JW,Lentz CW,Jimenez DF,et al.Cerebral salt wasting syndrome following brain injury in three pediatric patients:suggestions for rapid diagnosis and therapy[J].Pediatr Neurosurg,2002,36(2):75-79.
  • 6陈立朝,许民辉,邹咏文,陈广鑫.颅脑损伤并发抗利尿激素分泌异常综合征临床分析[J].创伤外科杂志,2003,5(6):406-408. 被引量:13

二级参考文献1

  • 1朱明权 孙丕珍 李昌臣 等.肺癌并发抗利尿激素分泌不适当综合征3例报告.中华内分泌代谢杂志,1988,4(3):184-184.

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